logo CaMPDB: Calpain for Modulatory Proteolysis Database

CL0010 : Chain A, Crystal Structure Of A Mu-Like Calpain

[ CaMP Format ]

* Basic Information

OrganismRattus norvegicus (Norway rat)
Protein NamesCalpain-2 catalytic subunit;; Calpain-2 large subunit; Calcium-activated neutral proteinase 2; CANP 2; Calpain M-type; M-calpain; Millimolar-calpain
Gene NamesCapn2
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
1QXP_A N/A N/A Q07009 N/A N/A N/A rno:29154

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 900 aa

Average Mass: 103.383 kDa

Monoisotopic Mass: 103.318 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Peptidase_C2 1. 45344754.29.3e-224
Calpain_III 1. 355511365.01.4e-106
efhand 1. 57860616.60.11
efhand 2. 60863618.50.027
efhand 3. 6737003.29.5
efhand 4. 77580318.40.03
efhand 5. 8058337.92.9
efhand 6. 8708977.53.2

3. Sequence Information

Fasta Sequence: CL0010.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1DF0 (X-ray; 260 A; A=1-700), 1MDW (X-ray; 195 A; A/B=19-346), 1QXP (X-ray; 280 A; A/B=-), 1U5I (X-ray; 286 A; A=1-700)

* References

[PubMed ID: 14656436] Pal GP, De Veyra T, Elce JS, Jia Z, Crystal structure of a micro-like calpain reveals a partially activated conformation with low Ca2+ requirement. Structure. 2003 Dec;11(12):1521-6.