logo CaMPDB: Calpain for Modulatory Proteolysis Database

CL0038 : neutral protease large subunit

[ CaMP Format ]

* Basic Information

OrganismHomo sapiens (human)
Protein NamesCalpain-2 catalytic subunit;; Calpain-2 large subunit; Calcium-activated neutral proteinase 2; CANP 2; Calpain M-type; M-calpain; Millimolar-calpain; Calpain large polypeptide L2
Gene NamesCANP; CANPL2
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
AAA35645 N/A N/A P17655 N/A N/A N/A hsa:824

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 700 aa

Average Mass: 80.006 kDa

Monoisotopic Mass: 79.956 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Peptidase_C2 1. 45344808.06.2e-240
Calpain_III 1. 355510393.63.4e-115
efhand 1. 57660420.40.0074
efhand 2. 60663419.40.015
efhand 3. 6716994.07.6

3. Sequence Information

Fasta Sequence: CL0038.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1KFU (X-ray; 250 A; L=1-700), 1KFX (X-ray; 315 A; L=1-700), 2NQA (X-ray; 220 A; A=43-346)

* References

[PubMed ID: 2852952] Imajoh S, Aoki K, Ohno S, Emori Y, Kawasaki H, Sugihara H, Suzuki K, Molecular cloning of the cDNA for the large subunit of the high-Ca2+-requiring form of human Ca2+-activated neutral protease. Biochemistry. 1988 Oct 18;27(21):8122-8.