logo CaMPDB: Calpain for Modulatory Proteolysis Database

CL0046 : calcium-dependent cysteine proteinase [Homo sapiens]

[ CaMP Format ]

* Basic Information

OrganismHomo sapiens (human)
Protein Namescalcium-dependent cysteine proteinase; Calpain-9; 3.4.22.-; Digestive tract-specific calpain; New calpain 4; nCL-4; Protein CG36
Gene NamesnCL-4; NCL4
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
AAB80762 N/A N/A O14815 N/A N/A N/A hsa:10753

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 690 aa

Average Mass: 79.097 kDa

Monoisotopic Mass: 79.047 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Peptidase_C2 1. 42337642.15.4e-190
Calpain_III 1. 348494355.01.4e-103
NUC153 1. 520551-3.43.6
efhand 1. 56559327.26.9e-05
efhand 2. 59562321.60.0032

3. Sequence Information

Fasta Sequence: CL0046.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1ZIV (X-ray; 231 A; A=26-347), 2P0R (X-ray; 250 A; A/B=10-340)

* References

[PubMed ID: 9524069] Lee HJ, Sorimachi H, Jeong SY, Ishiura S, Suzuki K, Molecular cloning and characterization of a novel tissue-specific calpain predominantly expressed in the digestive tract. Biol Chem. 1998 Feb;379(2):175-83.