logo CaMPDB: Calpain for Modulatory Proteolysis Database

CL0890 : calpain 2

[ CaMP Format ]

* Basic Information

OrganismHomo sapiens (human)
Protein Nameslarge subunit; calpain; large polypeptide L2; calcium-activated neutral proteinase; Calpain 2; large [catalytic] subunit; calpain 2, large subunit [Homo sapiens]; Calpain-2 catalytic subunit;; Calpain-2 large subunit; Calcium-activated neutral proteinase 2; CANP 2; Calpain M-type; M-calpain; Millimolar-calpain; Calpain large polypeptide L2
Gene NamesCAPN2; CANPL2; calpain 2, (m/II) large subunit
Gene Locus1q41-q42; chromosome 1
GO FunctionGO:0004198 - calpain activity [Evidence IEA]; GO:0005509 - calcium ion binding [Evidence IEA]
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_001739 NM_001748 824 P17655 114230 1479 N/A hsa:824

* Information From OMIM

Description: The calpains, or calcium-activated neutral proteases (EC, are nonlysosomal intracellular cysteine proteases. The mammalian calpains include 2 ubiquitous proteins, CAPN1 (OMIM:114220) and CAPN2, 2 stomach-specific proteins, and CAPN3 (OMIM:114240), which is muscle-specific. The ubiquitous enzymes are heterodimers with distinct large subunits associated with a common small subunit (CAPNS1; OMIM:114170), all of which are encoded by different genes.

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* Structure Information

1. Primary Information

Length: 700 aa

Average Mass: 80.006 kDa

Monoisotopic Mass: 79.956 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Peptidase_C2 1. 45344808.06.2e-240
Calpain_III 1. 355510393.63.4e-115
efhand 1. 57660420.40.0074
efhand 2. 60663419.40.015
efhand 3. 6716994.07.6

3. Sequence Information

Fasta Sequence: CL0890.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1KFU (X-ray; 250 A; L=1-700), 1KFX (X-ray; 315 A; L=1-700), 2NQA (X-ray; 220 A; A=43-346)

* References

[PubMed ID: 17359359] Medana IM, Day NP, Hien TT, Mai NT, Bethell D, Phu NH, Turner GD, Farrar J, White NJ, Esiri MM, Cerebral calpain in fatal falciparum malaria. Neuropathol Appl Neurobiol. 2007 Apr;33(2):179-92.

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