logo CaMPDB: Calpain for Modulatory Proteolysis Database

CL0891 : calpain 5

[ CaMP Format ]

* Basic Information

OrganismHomo sapiens (human)
Protein Namescalpain 5 [Homo sapiens]; Calpain-5; 3.4.22.-; New calpain 3; nCL-3; htra-3
Gene NamesCAPN5; NCL3; calpain 5
Gene Locus11q14; chromosome 11
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_004046 NM_004055 726 O15484 602537 1482 N/A hsa:726

* Information From OMIM

Description: Calpains are calcium-dependent cysteine proteases involved in signal transduction in a variety of cellular processes. A functional calpain protein consists of an invariant small subunit (OMIM:114170) and 1 of a family of large subunits.

* Structure Information

1. Primary Information

Length: 640 aa

Average Mass: 73.169 kDa

Monoisotopic Mass: 73.123 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Peptidase_C2 1. 26343435.96.4e-128
Calpain_III 1. 353496275.21.5e-79
C2 1. 51959654.73.4e-13

3. Sequence Information

Fasta Sequence: CL0891.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* References

[PubMed ID: 18787380] Hidalgo M, Saez ME, Martinez-Tello FJ, Moron FJ, Ferrero-Herrero E, Labalde-Martinez M, Rigopoulou D, Ballestin-Carcavilla C, Ruiz A, Royo JL, Ramirez-Lorca R, Absence of allelic imbalance involving EMSY, CAPN5, and PAK1 genes in papillary thyroid carcinoma. J Endocrinol Invest. 2008 Jul;31(7):618-23.

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