logo CaMPDB: Calpain for Modulatory Proteolysis Database

CL0892 : calpain 1

[ CaMP Format ]

* Basic Information

OrganismHomo sapiens (human)
Protein Nameslarge subunit; calcium-activated neutral proteinase; calpain; large polypeptide L1; cell proliferation-inducing protein 30; calpain 1, large subunit [Homo sapiens]; Calpain-1 catalytic subunit;; Calpain-1 large subunit; Calcium-activated neutral proteinase 1; CANP 1; Calpain mu-type; muCANP; Micromolar-calpain; Cell proliferation-inducing gene 30 protein
Gene NamesCAPN1; PIG30; CANPL1; calpain 1, (mu/I) large subunit
Gene Locus11q13; chromosome 11
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_005177 NM_005186 823 P07384 114220 1476 N/A hsa:823

* Information From OMIM

Description: Calpain (calcium-dependent protease; EC is an intracellular protease that requires calcium for its catalytic activity. Two isozymes, CANP1 and CANP2, with different calcium requirements, have been identified. Both are heterodimers composed of L (large, catalytic, 80 kD) and S (small, regulatory, 30 kD) subunits. The isozymes share an identical S subunit (CAPNS1; OMIM:114170), with the differences arising from the L subunits, L1 (CAPN1) and L2 (CAPN2; OMIM:114230).

» More (1)

* Structure Information

1. Primary Information

Length: 714 aa

Average Mass: 81.890 kDa

Monoisotopic Mass: 81.838 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Peptidase_C2 1. 55354814.66.2e-242
Calpain_III 1. 365522386.74.1e-113
efhand 1. 5465731.116
efhand 2. 58961716.60.11
efhand 3. 61964718.50.028
efhand 4. 6847116.24.5

3. Sequence Information

Fasta Sequence: CL0892.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1ZCM (X-ray; 200 A; A=33-353), 2ARY (X-ray; 240 A; A/B=27-360)

* References

[PubMed ID: 18806756] Norberg E, Gogvadze V, Ott M, Horn M, Uhlen P, Orrenius S, Zhivotovsky B, An increase in intracellular Ca2+ is required for the activation of mitochondrial calpain to release AIF during cell death. Cell Death Differ. 2008 Dec;15(12):1857-64. Epub 2008 Sep 19.

» More (10)