logo CaMPDB: Calpain for Modulatory Proteolysis Database

CL0895 : calpain 11

[ CaMP Format ]

* Basic Information

OrganismHomo sapiens (human)
Protein Namescalpain 11 [Homo sapiens]; Calpain-11; 3.4.22.-; Calcium-activated neutral proteinase 11; CANP 11
Gene NamesCAPN11; calpain 11
Gene Locus6p12; chromosome 6
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_008989 NM_007058 11131 Q9UMQ6 604822 1478 N/A hsa:11131

* Information From OMIM

Text: Calpains are a superfamily of related proteins, some of which have been shown to function as intracellular calcium-dependent cysteine proteases. Calpains consist of a variable large (80 kD) subunit and an invariant small (30 kD) subunit (CAPN4; OMIM:114170). By searching an EST database with the protein sequences of known vertebrate calpains, Dear et al. (1999) identified a calpain-11 (CAPN11) EST. The complete CAPN11 coding sequence encodes a deduced 702-amino acid protein with similarity to the large subunits of calpains. CAPN11 can be subdivided into the 4 domains typical of calpains. Domain II shows the characteristics of a protease domain and contains the cysteine, histidine, and asparagine residues that are part of the active site of cysteine proteases. Domain IV contains 5 putative calcium-binding EF-hand motifs. Dear et al. (1999) concluded that CAPN11 is likely to have protease activity and calcium-binding ability. Compared to all known calpains, CAPN11 shared the greatest sequence homology, 57.5%, with chicken mu/m calpain. Sequence homology between CAPN11 and known human calpains ranged from 54.3% with CAPN1 (OMIM:114220) to 18.7% with CAPN6 (OMIM:300146). Dot blot analysis of RNA from 50 different human tissues showed highest expression of CAPN11 in testis. Northern blot analysis of a variety of human tissues detected an approximately 3-kb CAPN11 transcript in testis.

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* Structure Information

1. Primary Information

Length: 702 aa

Average Mass: 80.583 kDa

Monoisotopic Mass: 80.531 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Peptidase_C2 1. 42341614.11.4e-181
Calpain_III 1. 352510279.01.1e-80
efhand 1. 57760524.40.00045
efhand 2. 60763522.40.0019

3. Sequence Information

Fasta Sequence: CL0895.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* References

[PubMed ID: 10409436] Dear TN, Moller A, Boehm T, CAPN11: A calpain with high mRNA levels in testis and located on chromosome 6. Genomics. 1999 Jul 15;59(2):243-7.

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