logo CaMPDB: Calpain for Modulatory Proteolysis Database

CL0904 : calpain 6

[ CaMP Format ]

* Basic Information

OrganismHomo sapiens (human)
Protein Namescalpain-like protease; calpamodulin; calpain 6 [Homo sapiens]; Calpain-6; Calpamodulin; CalpM; Calpain-like protease X-linked
Gene NamesCAPN6; CALPM, CANPX; CALPM; CANPX; calpain 6
Gene LocusXq23; chromosome X
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_055104 NM_014289 827 Q9Y6Q1 300146 1483 N/A hsa:827

* Information From OMIM

Text: Calpains are calcium-dependent cysteine proteases involved in signal transduction in a variety of cellular processes. A functional calpain protein consists of an invariant small subunit (OMIM:114170) and 1 of a family of large subunits. Dear et al. (1997) used degenerate PCR on mouse genomic DNA to isolate fragments of 2 novel calpains, CAPN5 (OMIM:602537) and CAPN6. The authors assembled a partial cDNA sequence of CAPN6 from several clones in an EST database. Dear et al. (1997) noted that CAPN5 and CAPN6 differ from previously identified vertebrate calpains in that they lack a calmodulin-like domain IV. CAPN6 may be an atypical calpain because it contains only 1 of the 3 conserved cysteine protease active site residues. By RNA dot blot and Northern blot analyses, Dear et al. (1997) found that CAPN6 is expressed as a 4.0-kb transcript predominantly in placenta.

* Structure Information

1. Primary Information

Length: 641 aa

Average Mass: 74.576 kDa

Monoisotopic Mass: 74.529 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Peptidase_C2 1. 26344283.35.6e-82
Calpain_III 1. 350495274.22.9e-79
C2 1. 51859755.02.8e-13

3. Sequence Information

Fasta Sequence: CL0904.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* References

[PubMed ID: 18657900] Rho SB, Byun HJ, Park SY, Chun T, Calpain 6 supports tumorigenesis by inhibiting apoptosis and facilitating angiogenesis. Cancer Lett. 2008 Nov 28;271(2):306-13. Epub 2008 Jul 26.

» More (5)