logo CaMPDB: Calpain for Modulatory Proteolysis Database

CL0905 : calpain 7

[ CaMP Format ]

* Basic Information

OrganismHomo sapiens (human)
Protein Namescalpain like protease; homolog of Aspergillus Nidulans PALB; calpain 7 [Homo sapiens]; Calpain 7
Gene NamesCAPN7; calpain 7
Gene Locus3p24; chromosome 3
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_055111 NM_014296 23473 Q7Z479 606400 1484 N/A hsa:23473

* Information From OMIM

Text: Calpain is an intracellular, nonlysosomal cysteine protease whose activity is regulated by calcium. Micro- and millicalpains (CAPN1, OMIM:114220, and CAPN2, OMIM:114230, respectively), which differ in their calcium requirements for protease activity, are ubiquitously expressed. Other calpains are expressed in specific tissues, such as CAPN3 (OMIM:114240) and CAPN9 (OMIM:606401), which are predominant in skeletal muscle and gastrointestinal tissue, respectively (Huang and Wang, 2001).

* Structure Information

1. Primary Information

Length: 813 aa

Average Mass: 92.652 kDa

Monoisotopic Mass: 92.594 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
MIT 1. 67156.21.3e-13
MIT 2. 8615464.44.1e-16
Peptidase_C2 1. 2465373.43.4e-14
Sklp_toxin 1. 565634-13.69.7
Calpain_III 1. 685810-20.92.2e-05

3. Sequence Information

Fasta Sequence: CL0905.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* References

[PubMed ID: 11342116] Futai E, Kubo T, Sorimachi H, Suzuki K, Maeda T, Molecular cloning of PalBH, a mammalian homologue of the Aspergillus atypical calpain PalB. Biochim Biophys Acta. 2001 Jan 26;1517(2):316-9.

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