logo CaMPDB: Calpain for Modulatory Proteolysis Database

CL0913 : calpain 10 isoform a

[ CaMP Format ]

* Basic Information

OrganismHomo sapiens (human)
Protein Namescalcium-activated neutral protease; calpain 10 isoform a [Homo sapiens]; Calpain-10; 3.4.22.-; Calcium-activated neutral proteinase 10; CANP 10
Gene NamesCAPN10; KIAA1845; calpain 10
Gene Locus2q37.3; chromosome 2
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_075571 NM_023083 11132 Q9HC96 605286 1477 N/A hsa:11132

* Information From OMIM

Function: The results of Horikawa et al. (2000) suggested a novel pathway involved in the pathophysiology of diabetes, one that may include, in addition to calpain-10, its substrates, inhibitors, and activators. Calpain-10 may represent the third example of a protease contributing to the development of diabetes, the others being prohormone-processing carboxypeptidase E (OMIM:114855) and prohormone convertase-1 (OMIM:162150), both of which are associated with diabetes and obesity.

» More (2)

* Structure Information

1. Primary Information

Length: 672 aa

Average Mass: 74.938 kDa

Monoisotopic Mass: 74.891 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Peptidase_C2 1. 13316182.51.2e-51
Calpain_III 1. 33849431.41.8e-09
Calpain_III 2. 51364514.83.6e-08

3. Sequence Information

Fasta Sequence: CL0913.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* References

[PubMed ID: 18936436] Chang MH, Lindegren ML, Butler MA, Chanock SJ, Dowling NF, Gallagher M, Moonesinghe R, Moore CA, Ned RM, Reichler MR, Sanders CL, Welch R, Yesupriya A, Khoury MJ, Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994. Am J Epidemiol. 2009 Jan 1;169(1):54-66. Epub 2008 Oct 20.

» More (9)