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CL0949 : calpain 3 isoform c

[ CaMP Format ]

* Basic Information

OrganismHomo sapiens (human)
Protein Namescalpain; large polypeptide L3; calpain p94; large [catalytic] subunit; muscle-specific calcium-activated neutral protease 3 large subunit; calpain 3 isoform c [Homo sapiens]; Calpain-3; 3.4.22.54; Calpain L3; Calpain p94; Calcium-activated neutral proteinase 3; CANP 3; Muscle-specific calcium-activated neutral protease 3; New calpain 1; nCL-1
Gene NamesCAPN3; CANP3, CANPL3, NCL1; CANP3; CANPL3; NCL1; calpain 3, (p94)
Gene Locus15q15.1-q21.1; chromosome 15
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_775110 NM_173087 825 P20807 114240 1480 N/A hsa:825

* Information From OMIM

Description: The CAPN3 gene encodes calpain-3. The calpains, or calcium-activated neutral proteases (EC 3.4.22.17), are nonlysosomal intracellular cysteine proteases. Mammalian calpains are heterodimers composed of a ubiquitous 80-kD large subunit (e.g., CAPN1, OMIM:114220 and CAPN2, OMIM:114230) and a common small 30-kD subunit (CAPNS1; OMIM:114170). CAPN3 is a muscle-specific large subunit (Sorimachi et al., 1989).

* Structure Information

1. Primary Information

Length: 729 aa

Average Mass: 84.089 kDa

Monoisotopic Mass: 84.036 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Peptidase_C2 1. 74369802.52.7e-238
Calpain_III 1. 380534367.32.8e-107
Osmo_CC 1. 5515962.96
efhand 1. 60463227.94e-05
efhand 2. 63466226.79.3e-05
efhand 3. 6997269.12.2

3. Sequence Information

Fasta Sequence: CL0949.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1Y9V (Model; -; A/B=649-821)

* References

[PubMed ID: 19048948] Shirafuji T, Otsuka Y, Kobessho H, Minami N, Hayashi Y, Nishino I, Kanda F, [Case of LGMD2A (calpainopathy) clinically presenting as Miyoshi distal myopathy] Rinsho Shinkeigaku. 2008 Sep;48(9):651-5.

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