logo CaMPDB: Calpain for Modulatory Proteolysis Database

CL0966 : calpain 3 isoform g

[ CaMP Format ]

* Basic Information

OrganismHomo sapiens (human)
Protein Namescalpain; large polypeptide L3; calpain p94; large [catalytic] subunit; muscle-specific calcium-activated neutral protease 3 large subunit; calpain 3 isoform g [Homo sapiens]
Gene NamesCAPN3; calpain 3, (p94)
Gene Locus15q15.1-q21.1; chromosome 15
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_997629 NM_212464 825 N/A 114240 1480 N/A N/A

* Information From OMIM

Description: The CAPN3 gene encodes calpain-3. The calpains, or calcium-activated neutral proteases (EC 3.4.22.17), are nonlysosomal intracellular cysteine proteases. Mammalian calpains are heterodimers composed of a ubiquitous 80-kD large subunit (e.g., CAPN1, OMIM:114220 and CAPN2, OMIM:114230) and a common small 30-kD subunit (CAPNS1; OMIM:114170). CAPN3 is a muscle-specific large subunit (Sorimachi et al., 1989).

* Structure Information

1. Primary Information

Length: 426 aa

Average Mass: 49.029 kDa

Monoisotopic Mass: 48.998 kDa

2. Domain Information

Annotated Domains: Not Available.

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Peptidase_C2 1. 1330829.91.5e-246
Calpain_III 1. 341426102.02.1e-27

3. Sequence Information

Fasta Sequence: CL0966.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* References

[PubMed ID: 19048948] Shirafuji T, Otsuka Y, Kobessho H, Minami N, Hayashi Y, Nishino I, Kanda F, [Case of LGMD2A (calpainopathy) clinically presenting as Miyoshi distal myopathy] Rinsho Shinkeigaku. 2008 Sep;48(9):651-5.

» More (10)