CL0966 : calpain 3 isoform g
[ CaMP Format ]
* Basic Information
| Organism | Homo sapiens (human) |
| Protein Names | calpain; large polypeptide L3; calpain p94; large [catalytic] subunit; muscle-specific calcium-activated neutral protease 3 large subunit; calpain 3 isoform g [Homo sapiens] |
| Gene Names | CAPN3; calpain 3, (p94) |
| Gene Locus | 15q15.1-q21.1; chromosome 15 |
| GO Function | Not available |
* Information From OMIM
Description: The CAPN3 gene encodes calpain-3. The calpains, or calcium-activated neutral proteases (EC 3.4.22.17), are nonlysosomal intracellular cysteine proteases. Mammalian calpains are heterodimers composed of a ubiquitous 80-kD large subunit (e.g., CAPN1, OMIM:114220 and CAPN2, OMIM:114230) and a common small 30-kD subunit (CAPNS1; OMIM:114170). CAPN3 is a muscle-specific large subunit (Sorimachi et al., 1989).
* Structure Information
1. Primary Information
Length: 426 aa
Average Mass: 49.029 kDa
Monoisotopic Mass: 48.998 kDa
2. Domain Information
Annotated Domains: Not Available.
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| Peptidase_C2 1. | 1 | 330 | 829.9 | 1.5e-246 |
| Calpain_III 1. | 341 | 426 | 102.0 | 2.1e-27 |
3. Sequence Information
Fasta Sequence: CL0966.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* References
[PubMed ID: 19048948] Shirafuji T, Otsuka Y, Kobessho H, Minami N, Hayashi Y, Nishino I, Kanda F, [Case of LGMD2A (calpainopathy) clinically presenting as Miyoshi distal myopathy] Rinsho Shinkeigaku. 2008 Sep;48(9):651-5.