logo CaMPDB: Calpain for Modulatory Proteolysis Database

CL0987 : Calpain-3

[ CaMP Format ]

* Basic Information

OrganismHomo sapiens (human)
Protein NamesCalpain L3; Calpain p94; Calcium-activated neutral proteinase 3; CANP 3; Muscle-specific calcium-activated neutral protease 3; New calpain 1; nCL-1; 3.4.22.54
Gene NamesCANP3, CANPL3, NCL1; CANP3; CANPL3; NCL1
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
P20807 N/A N/A P20807 N/A N/A N/A hsa:825

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 821 aa

Average Mass: 94.254 kDa

Monoisotopic Mass: 94.194 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Peptidase_C2 1. 74417942.22.4e-280
Calpain_III 1. 428582367.32.8e-107
Osmo_CC 1. 6436882.96
efhand 1. 69672427.94e-05
efhand 2. 72675426.79.3e-05
efhand 3. 7918189.12.2

3. Sequence Information

Fasta Sequence: CL0987.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1Y9V (Model; -; A/B=649-821)

* References

[PubMed ID: 7720071] Richard I, Broux O, Allamand V, Fougerousse F, Chiannilkulchai N, Bourg N, Brenguier L, Devaud C, Pasturaud P, Roudaut C, et al., Mutations in the proteolytic enzyme calpain 3 cause limb-girdle muscular dystrophy type 2A. Cell. 1995 Apr 7;81(1):27-40.

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