logo CaMPDB: Calpain for Modulatory Proteolysis Database

CT0106 : calpastatin isoform a [Homo sapiens]

[ CaMP Format ]

* Basic Information

OrganismHomo sapiens (human)
Protein Namescalpastatin isoform a; calpain inhibitor; sperm BS-17 component; heart-type calpastatin; Calpastatin; Calpain inhibitor; Sperm BS-17 component
Gene NamesCAST; calpastatin
Gene Locus5q15; chromosome 5
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_001741 NM_001750 831 P20810 114090 1515 N/A hsa:831

* Information From OMIM

Text: Calpastatin is the natural inhibitor of calpain (OMIM:114170). In erythrocytes of patients with essential hypertension (OMIM:145500), the level of calpastatin activity has been found to be significantly lower than in the red cells of normotensive subjects. Pontremoli et al. (1988) demonstrated by Western blot analysis that the decreased inhibitor activity is the result of a decrease in the amount of the inhibitor protein. Calpastatin isolated and purified from erythrocytes of normotensive and hypertensive patients had identical specific activities. Pontremoli et al. (1988) also presented evidence indicating that the decreased level of calpastatin cannot be ascribed to accelerated decay during the red cell life span. Using a cDNA probe encoding the 5-prime terminal region of CAST for spot-blot analysis of sorted chromosomes and chromosomal in situ hybridization, Inazawa et al. (1990) assigned the CAST gene to 5q14-q22. Inazawa et al. (1991) mapped CAST to 5q15-q21 by 2 methods of in situ hybridization and confirmed the results by spot-blot analysis of sorted chromosomes. Mimori et al. (1995) demonstrated that anti-calpastatin autoantibodies are present in as many as 57% of rheumatoid arthritis patients and concluded that they may participate in pathogenic mechanisms of this and other rheumatic diseases which showed a lower frequency.

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* Structure Information

1. Primary Information

Length: 791 aa

Average Mass: 84.943 kDa

Monoisotopic Mass: 84.891 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Asr 1. 1081276.412
Calpain_inhib 1. 182307178.71.7e-50
Calpain_inhib 2. 315441195.41.6e-55
Calpain_inhib 3. 452584220.83.5e-63
Calpain_inhib 4. 595721227.14.4e-65

3. Sequence Information

Fasta Sequence: CT0106.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* References