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SB0002 : Integrin [beta]2

[ CaMP Format ]

* Basic Information

OrganismHomo sapiens (human)
Protein Namesintegrin beta-2 precursor [Homo sapiens]; integrin beta-2 precursor; integrin beta-2; leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C; complement receptor C3 beta-subunit; cell surface adhesion glycoprotein (LFA-1/CR3/P150,959 beta subunit precursor); leukocyte cell adhesion molecule CD18; integrin beta chain, beta 2; Integrin beta-2; Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; Complement receptor C3 subunit beta
Gene NamesITGB2; CD18, MFI7; CD18; MFI7; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
Gene Locus21q22.3; chromosome 21
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_000202 NM_000211 3689 P05107 600065 HGNC:6155 N/A hsa:3689

* Information From OMIM

Description: The leukocyte cell adhesion molecule belongs to the class of cell membrane glycoproteins known as integrins, which are alpha-beta heterodimers. The alpha subunits vary in size from 120 to 180 kD and each is noncovalently associated with a beta subunit (90 to 110 kD). There are 8 known beta subunits and 14 known alpha subunits. Although the alpha and beta subunits could in theory associate to give more than 100 integrin heterodimers, the diversity is restricted and different combinations are associated with different cell types (Hynes, 1992).

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* Structure Information

1. Primary Information

Length: 769 aa

Average Mass: 84.781 kDa

Monoisotopic Mass: 84.726 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Integrin beta tail domain 1. 253510.02.8
EGF-like domain 1. 3853897.00.2
EGF-like domain 2. 44445217.02.7
Integrin beta tail domain 2. 47550716.013.0
EGF-like domain 3. 53153719.00.3
EGF-like domain 4. 5415731.017.1
Integrin beta tail domain 3. 58858846.012.4
EGF-like domain 5. 61864314.08.4
Integrin beta cytoplasmic domain 1. 7247661.00.5
--- cleavage 744 (inside Integrin beta cytoplasmic domain 724..766) ---
--- cleavage 754 (inside Integrin beta cytoplasmic domain 724..766) ---
--- cleavage 760 (inside Integrin beta cytoplasmic domain 724..766) ---
--- cleavage 762 (inside Integrin beta cytoplasmic domain 724..766) ---

3. Sequence Information

Fasta Sequence: SB0002.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1JX3 (Model; -; A=126-364), 1L3Y (NMR; -; A=535-574), 1YUK (X-ray; 180 A; A=23-125, B=365-482), 2JF1 (X-ray; 220 A; T=735-769), 2P26 (X-ray; 175 A; A=23-535), 2P28 (X-ray; 220 A; A=23-122, B=362-574), 2V7D (X-ray; 250 A; P/Q/R/S=755-764), 3K6S (X-ray; 350 A; B/D/F/H=23-699), 3K71 (X-ray; 395 A; B/D/F/H=23-699), 3K72 (X-ray; 370 A; B/D=23-699), 4NEH (X-ray; 275 A; B=23-695), 4NEN (X-ray; 290 A; B=23-696)

* Cleavage Information

4 [sites] cleaved by Calpain 2

Source Reference: [PubMed ID: 10571053] Pfaff M, Du X, Ginsberg MH, Calpain cleavage of integrin beta cytoplasmic domains. FEBS Lett. 1999 Oct 22;460(1):17-22.

Cleavage sites (±10aa)


Lys744 Ser

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)


Phe754 Lys

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)


Thr760 Val

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)


Met762 Asn

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 24889201] Raftery MJ, Lalwani P, Krautkrmer E, Peters T, Scharffetter-Kochanek K, Kruger R, Hofmann J, Seeger K, Kruger DH, Schonrich G, beta2 integrin mediates hantavirus-induced release of neutrophil extracellular traps. J Exp Med. 2014 Jun 30;211(7):1485-97. doi: 10.1084/jem.20131092. Epub 2014 Jun

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