logo CaMPDB: Calpain for Modulatory Proteolysis Database

SB0004 : Calcium/calmodulin-dependent 3p,5p-cyclic nucleotide phosphodiesterase1A

[ CaMP Format ]

* Basic Information

OrganismBos taurus (cattle)
Protein Names61 kDa calmodulin-stimulated cyclic nucleotide phosphodiesterase [Bos taurus]; 61 kDa calmodulin-stimulated cyclic nucleotide phosphodiesterase; Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; Cam-PDE 1A;; 61 kDa Cam-PDE
Gene NamesCNP; PDE1A
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
AAA74560 N/A N/A P14100 N/A N/A N/A bta:281969

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 530 aa

Average Mass: 60.843 kDa

Monoisotopic Mass: 60.805 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
3'5'-cyclic nucleotide phosphodiesterase N-terminal 1. 731331.00.2
--- cleavage 126 (inside 3'5'-cyclic nucleotide phosphodiesterase N-terminal 73..133) ---
3'5'-cyclic nucleotide phosphodiesterase 1. 2184381.05.8

3. Sequence Information

Fasta Sequence: SB0004.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites]

Source Reference: [PubMed ID: 9784246] Kakkar R, Raju RV, Sharma RK, In vitro generation of an active calmodulin-independent phosphodiesterase from brain calmodulin-dependent phosphodiesterase (PDE1A2) by m-calpain. Arch Biochem Biophys. 1998 Oct 15;358(2):320-8.

Cleavage sites (±10aa)


Gln126 Ala

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 7678006] Sonnenburg WK, Seger D, Beavo JA, Molecular cloning of a cDNA encoding the "61-kDa" calmodulin-stimulated cyclic nucleotide phosphodiesterase. Tissue-specific expression of structurally related isoforms. J Biol Chem. 1993 Jan 5;268(1):645-52.