logo CaMPDB: Calpain for Modulatory Proteolysis Database

SB0005 : [beta]-II-spectrin, non-erythrocytic 1 isoform 1

[ CaMP Format ]

* Basic Information

OrganismHomo sapiens (human)
Protein Namesspectrin beta chain, non-erythrocytic 1 isoform 1 [Homo sapiens]; spectrin beta chain, non-erythrocytic 1 isoform 1; beta-G spectrin; beta-spectrin 2; beta-spectrin II; beta-fodrin; embryonic liver beta-fodrin; spectrin beta chain, brain 1; spectrin beta chain, non-erythrocytic 1; beta-spectrin non-erythrocytic 1; epididymis luminal protein 102; beta-II spectrin; fodrin beta chain; spectrin, non-erythroid beta chain 1; Spectrin beta chain, non-erythrocytic 1; Beta-II spectrin; Fodrin beta chain; Spectrin, non-erythroid beta chain 1
Gene NamesSPTBN1; SPTB2; spectrin, beta, non-erythrocytic 1
Gene Locus2p21; chromosome 2
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_003119 NM_003128 6711 Q01082 182790 HGNC:11275 N/A hsa:6711

* Information From OMIM

Description: Spectrin is a tetrameric cytoskeletal protein essential for determination of cell shape, resilience of membranes to mechanical stress, positioning of transmembrane proteins, and organization of organelles and molecular traffic. Alpha- and beta-spectrin subunits form antiparallel dimers that self associate to give the spectrin tetramer. Beta subunits, such as SPTBN1, contain most of the spectrin binding activity (Hayes et al., 2000).

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* Structure Information

1. Primary Information

Length: 2364 aa

Average Mass: 274.606 kDa

Monoisotopic Mass: 274.439 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Spectrin repeat 1. 82672.00.0
CAMSAP CH domain 1. 729510.00.0
CAMSAP CH domain 2. 19325611.00.1
Centromere-associated protein K 1. 3824479.01.9
Spectrin repeat 2. 5306363.00.0
Spectrin repeat 3. 6397422.03.3
Spectrin repeat 4. 7458472.00.6
Centromere-associated protein K 2. 88094690.00.9
Calponin homology (CH) domain 1. 9679967.00.0
Domain of unknown function (DUF1843) 1. 1010102338.00.4
Domain of unknown function (DUF1843) 2. 1045107117.00.0
Putative tight adherence pilin protein F 1. 1076111856.00.3
Spectrin repeat 5. 117012582.02.1
Calponin homology (CH) domain 2. 1269130852.00.1
PH domain 1. 1383140285.00.0
Putative tight adherence pilin protein F 2. 1415145549.01.4
Centromere-associated protein K 3. 1519164247.012.0
Putative tight adherence pilin protein F 3. 1730177646.00.0
Centromere-associated protein K 4. 1794189873.00.9
Centromere-associated protein K 5. 19802005146.00.1
Spectrin repeat 6. 201820972.01.5
--- cleavage 2066 (inside Spectrin repeat 2018..2097) ---
Spectrin repeat 7. 229023118.00.1

3. Sequence Information

Fasta Sequence: SB0005.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1AA2 (X-ray; 200 A; A=173-280), 1BKR (X-ray; 110 A; A=172-280), 3EDV (X-ray; 195 A; A/B=1697-2015)

* Cleavage Information

1 [sites] cleaved by Calpain 1

Source Reference: [PubMed ID: 9989581] Lofvenberg L, Backman L, Calpain-induced proteolysis of beta-spectrins. FEBS Lett. 1999 Jan 25;443(2):89-92.

Cleavage sites (±10aa)


Ala2066 Ala

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 22798246] Deng YH, Zhao L, Zhang MJ, Pan CM, Zhao SX, Zhao HY, Sun LH, Tao B, Song HD, Wang WQ, Ning G, Liu JM, The influence of the genetic and non-genetic factors on bone mineral density and osteoporotic fractures in Chinese women. Endocrine. 2013 Feb;43(1):127-35. doi: 10.1007/s12020-012-9726-8. Epub 2012 Jul

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