logo CaMPDB: Calpain for Modulatory Proteolysis Database

SB0006 : Calcium/calmodulin-dependent protein kinase IV

[ CaMP Format ]

* Basic Information

OrganismMus musculus (house mouse)
Protein Namescalcium/calmodulin-dependent protein kinase IV [Mus musculus]; calcium/calmodulin-dependent protein kinase IV; Ca2+/calmodulin-dependent protein kinase type IV/Gr; Calcium/calmodulin-dependent protein kinase type IV; CaMK IV;; CaM kinase-GR
Gene NamesCamk4; calcium/calmodulin-dependent protein kinase IV
Gene Locus18 12.0 cM; chromosome 18
GO FunctionGO:0005524 - ATP binding [Evidence IEA]; GO:0016301 - kinase activity [Evidence IEA]; GO:0005515 - protein binding [Evidence IPI]; GO:0005516 - calmodulin binding [Evidence IEA]; GO:0000166 - nucleotide binding [Evidence IEA]; GO:0005509 - calcium ion binding [Evidence IEA]; GO:0016740 - transferase activity [Evidence IEA]; GO:0004672 - protein kinase activity [Evidence IEA]; GO:0016563 - transcriptional activator activity [Evidence IMP]; GO:0004674 - protein serine/threonine kinase activity [Evidence IEA]; GO:0004683 - calmodulin regulated protein kinase activity [Evidence TAS]
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_033923 NM_009793 12326 P08414 N/A N/A N/A mmu:12326

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 469 aa

Average Mass: 52.627 kDa

Monoisotopic Mass: 52.594 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
--- cleavage 23 ---
Kinase-like 1. 477219.00.0
Phosphotransferase enzyme family 1. 138173148.00.0
--- cleavage 199 ---
Protein tyrosine kinase 1. 35941223.00.1

3. Sequence Information

Fasta Sequence: SB0006.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

2 [sites] cleaved by Calpain 2

Source Reference: [PubMed ID: 9685336] McGinnis KM, Whitton MM, Gnegy ME, Wang KK, Calcium/calmodulin-dependent protein kinase IV is cleaved by caspase-3 and calpain in SH-SY5Y human neuroblastoma cells undergoing apoptosis. J Biol Chem. 1998 Aug 7;273(32):19993-20000.

Cleavage sites (±10aa)


Asn23 Leu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)


Gly199 Thr

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 17394138] Saino-Saito S, Cave JW, Akiba Y, Sasaki H, Goto K, Kobayashi K, Berlin R, Baker H, ER81 and CaMKIV identify anatomically and phenotypically defined subsets of mouse olfactory bulb interneurons. J Comp Neurol. 2007 Jun 1;502(4):485-96.

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