logo CaMPDB: Calpain for Modulatory Proteolysis Database

SB0007 : Glutamate receptor, metabotropic 1

[ CaMP Format ]

* Basic Information

OrganismRattus norvegicus (Norway rat)
Protein Namesmetabotropic glutamate receptor 1 isoform alpha precursor [Rattus norvegicus]; metabotropic glutamate receptor 1 isoform alpha precursor; metabotropic glutamate receptor 1; mGluR1; G protein coupled receptor family C group 1 member A; Metabotropic glutamate receptor 1
Gene NamesGrm1; Gprc1a, Mglur1; Gprc1a; Mglur1; glutamate receptor, metabotropic 1
Gene Locus1p13; chromosome 1
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_058707 NM_017011 24414 P23385 N/A N/A N/A rno:24414

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 1199 aa

Average Mass: 133.235 kDa

Monoisotopic Mass: 133.151 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
P-loop containing NTP hydrolase pore-1 1. 270311195.00.0
Nine Cysteines Domain of family 3 GPCR 1. 5215712.010.4
7 transmembrane sweet-taste receptor of 3 GCPR 1. 6048371.027.4
--- cleavage 936 ---
Homer-binding domain of metabotropic glutamate receptor 1. 114911991.09.5

3. Sequence Information

Fasta Sequence: SB0007.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1EWK (X-ray; 220 A; A/B=33-522), 1EWT (X-ray; 370 A; A/B=33-522), 1EWV (X-ray; 400 A; A/B=33-522), 1ISR (X-ray; 400 A; A=33-522), 1ISS (X-ray; 330 A; A/B=33-522)

* Cleavage Information

1 [sites] cleaved by Calpain 1

Source Reference: [PubMed ID: 17270736] Xu W, Wong TP, Chery N, Gaertner T, Wang YT, Baudry M, Calpain-mediated mGluR1alpha truncation: a key step in excitotoxicity. Neuron. 2007 Feb 1;53(3):399-412.

Cleavage sites (±10aa)


Ser936 Tyr

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 23978512] Fan W, Group I metabotropic glutamate receptors modulate late phase long-term potentiation in hippocampal CA1 pyramidal neurons: comparison of apical and basal dendrites. Neurosci Lett. 2013 Oct 11;553:132-7. doi: 10.1016/j.neulet.2013.08.030. Epub

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