logo CaMPDB: Calpain for Modulatory Proteolysis Database

SB0008 : Phosphoinositide-specific phospholipase C[beta]1

[ CaMP Format ]

* Basic Information

OrganismBos taurus (cattle)
Protein Names1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [Bos taurus]; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1; PLC-I; PLC-154; PLC-beta-1; phospholipase C-beta-1; phosphoinositide phospholipase C; phosphoinositide phospholipase C-beta-1;; Phosphoinositide phospholipase C-beta-1; Phospholipase C-beta-1
Gene NamesPLCB1; phospholipase C, beta 1 (phosphoinositide-specific)
Gene Locus13; chromosome 13
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_777242 NM_174817 287026 P10894 N/A N/A N/A bta:287026

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 1216 aa

Average Mass: 138.713 kDa

Monoisotopic Mass: 138.628 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Domain of unknown function (DUF4510) 1. 138163112.00.0
Phosphoinositide-specific phospholipase C, efhand-like 1. 2243141.00.0
Phosphatidylinositol-specific phospholipase C, X domain 1. 3184681.00.0
Phosphatidylinositol-specific phospholipase C, Y domain 1. 5406551.01.2
Domain of unknown function (DUF4510) 2. 70775341.00.0
PLC-beta C terminal 1. 8168403.00.7
--- cleavage 880 ---
Phosphatidylinositol-specific phospholipase C, X domain 2. 91393298.00.3
Phosphatidylinositol-specific phospholipase C, X domain 3. 1047106794.01.3
Phosphatidylinositol-specific phospholipase C, X domain 4. 1115114295.00.5

3. Sequence Information

Fasta Sequence: SB0008.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites] cleaved by Calpain 2

Source Reference: [PubMed ID: 8429045] Park D, Jhon DY, Lee CW, Ryu SH, Rhee SG, Removal of the carboxyl-terminal region of phospholipase C-beta 1 by calpain abolishes activation by G alpha q. J Biol Chem. 1993 Feb 15;268(5):3710-4.

Cleavage sites (±10aa)


His880 Ser

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 19393038] Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Marcais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL, A whole-genome assembly of the domestic cow, Bos taurus. Genome Biol. 2009;10(4):R42. doi: 10.1186/gb-2009-10-4-r42. Epub 2009 Apr 24.

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