logo CaMPDB: Calpain for Modulatory Proteolysis Database

SB0009 : Neurofibromin 2, Merlin

[ CaMP Format ]

* Basic Information

OrganismHomo sapiens (human)
Protein Namesmerlin isoform 1 [Homo sapiens]; merlin isoform 1; moesin-ezrin-radixin like; neurofibromin 2 (bilateral acoustic neuroma); schwannomin; moesin-ezrin-radizin-like protein; schwannomerlin; merlin; neurofibromin-2; moesin-ezrin-radixin-like protein; Merlin; Moesin-ezrin-radixin-like protein; Neurofibromin-2; Schwannomerlin; Schwannomin
Gene NamesNF2; SCH; neurofibromin 2 (merlin)
Gene Locus22q12.2; chromosome 22
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_000259 NM_000268 4771 P35240 607379 HGNC:7773 06980 hsa:4771

* Information From OMIM

Description: Cell-cell contact between normal cultured diploid cells results in inhibition of proliferation despite the unlimited availability of nutrients and growth-promoting factors. A similar phenomenon occurs in vivo in all adult solid tissues. NF2 is a critical regulator of contact-dependent inhibition of proliferation and functions at the interface between cell-cell adhesion, transmembrane signaling, and the actin cytoskeleton (Curto and McClatchey, 2008).

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* Structure Information

1. Primary Information

Length: 595 aa

Average Mass: 69.689 kDa

Monoisotopic Mass: 69.646 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
FERM C-terminal PH-like domain 1. 205043.00.0
FERM C-terminal PH-like domain 2. 11212478.00.1
FERM C-terminal PH-like domain 3. 2263131.00.0
--- cleavage 294 (inside FERM C-terminal PH-like domain 226..313) ---
--- cleavage 298 (inside FERM C-terminal PH-like domain 226..313) ---
FERM central domain 1. 32836167.01.2
FERM central domain 2. 38147820.017.5
FERM N-terminal domain 1. 51954043.00.2

3. Sequence Information

Fasta Sequence: SB0009.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1H4R (X-ray; 180 A; A/B=1-313), 3U8Z (X-ray; 264 A; A/B/C/D=18-312)

* Cleavage Information

2 [sites] cleaved by Calpain 1 and 2

Source Reference: [PubMed ID: 9701243] Kimura Y, Koga H, Araki N, Mugita N, Fujita N, Takeshima H, Nishi T, Yamashima T, Saido TC, Yamasaki T, Moritake K, Saya H, Nakao M, The involvement of calpain-dependent proteolysis of the tumor suppressor NF2 (merlin) in schwannomas and meningiomas. Nat Med. 1998 Aug;4(8):915-22.

Cleavage sites (±10aa)


Lys294 Leu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)


Gln298 Leu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 24309211] Schulz A, Kyselyova A, Baader SL, Jung MJ, Zoch A, Mautner VF, Hagel C, Morrison H, Neuronal merlin influences ERBB2 receptor expression on Schwann cells through neuregulin 1 type III signalling. Brain. 2014 Feb;137(Pt 2):420-32. doi: 10.1093/brain/awt327. Epub 2013 Dec 5.

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