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SB0010 : Neurofilament medium polypeptide, Neurofilament 3

[ CaMP Format ]

* Basic Information

OrganismBos taurus (cattle)
Protein NamesPREDICTED: neurofilament, medium polypeptide [Bos taurus]; neurofilament, medium polypeptide
Gene NamesNEF3; Derived by automated computational analysis using gene prediction method: GNOMON. Supporting evidence includes similarity to: 1 mRNA, 94 ESTs, 40 Proteins
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
XP_582135 XM_582135 281347 N/A N/A N/A N/A N/A

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 931 aa

Average Mass: 103.612 kDa

Monoisotopic Mass: 103.551 kDa

2. Domain Information

Annotated Domains: Not Available.

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Protein of unknown function (DUF1664) 1. 17023456.03.4
Protein of unknown function (DUF1664) 2. 26435137.03.7
Protein of unknown function (DUF1664) 3. 36039447.00.1
Intermediate filament head (DNA binding) region 1. 4004245.00.0
Intermediate filament protein 1. 456556169.026.9
--- cleavage 467 (inside Intermediate filament protein 456..556) ---
--- cleavage 516 (inside Intermediate filament protein 456..556) ---
Intermediate filament protein 2. 72873586.04.2
Intermediate filament protein 3. 895914183.00.1

3. Sequence Information

Fasta Sequence: SB0010.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

2 [sites] cleaved by Calpain 1

Source Reference: [PubMed ID: 15530438] Shaw G, Yang C, Zhang L, Cook P, Pike B, Hill WD, Characterization of the bovine neurofilament NF-M protein and cDNA sequence, and identification of in vitro and in vivo calpain cleavage sites. Biochem Biophys Res Commun. 2004 Dec 10;325(2):619-25.

Cleavage sites (±10aa)


Lys467 Ser

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)


Lys516 Ala

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References