logo CaMPDB: Calpain for Modulatory Proteolysis Database

SB0013 : Solute carrier family 6, Gly transporter 2

[ CaMP Format ]

* Basic Information

OrganismRattus norvegicus (Norway rat)
Protein Namessodium- and chloride-dependent glycine transporter 2 [Rattus norvegicus]; sodium- and chloride-dependent glycine transporter 2; glycine transporter 2; glyT-2; solute carrier family 6 (neurotransmitter transporter, glycine), member 5; solute carrier family 6 member 5; Sodium- and chloride-dependent glycine transporter 2; GlyT-2; GlyT2; Solute carrier family 6 member 5
Gene NamesSlc6a5; Glyt2; solute carrier family 6 (neurotransmitter transporter), member 5
Gene Locus1q22; chromosome 1
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_976079 NM_203334 171148 P58295 N/A N/A N/A rno:171148

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 799 aa

Average Mass: 87.908 kDa

Monoisotopic Mass: 87.851 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
--- cleavage 156 ---
--- cleavage 164 ---
Protein of unknown function (DUF999) 1. 34539834.00.0
Protein of unknown function (DUF999) 2. 49154064.00.1

3. Sequence Information

Fasta Sequence: SB0013.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

2 [sites] cleaved by Calpain 1 and/or 2

Source Reference: [PubMed ID: 14675166] Baliova M, Betz H, Jursky F, Calpain-mediated proteolytic cleavage of the neuronal glycine transporter, GlyT2. J Neurochem. 2004 Jan;88(1):227-32.

Cleavage sites (±10aa)


Met156 Ser

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)


Gly164 Thr

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 23650557] Arribas-Gonzalez E, Alonso-Torres P, Aragon C, Lopez-Corcuera B, Calnexin-assisted biogenesis of the neuronal glycine transporter 2 (GlyT2). PLoS One. 2013 May 1;8(5):e63230. doi: 10.1371/journal.pone.0063230. Print 2013.

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