logo CaMPDB: Calpain for Modulatory Proteolysis Database

SB0016 : Connexin-49, Gap junction [alpha]-8

[ CaMP Format ]

* Basic Information

OrganismOvis aries (sheep)
Protein Namesconnexin 49 protein [Ovis aries]; connexin 49 protein; MP70; similar to Mus musculus connexin 50, Gallus gallu connexin 45.6, Homo sapiens connexin 50 proteins; Gap junction alpha-8 protein; Connexin-49; Cx49; Lens fiber protein MP70; MP38; MP64
Gene NamesGJA8
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
AAF01367 N/A N/A P55917 N/A N/A N/A oas:100170231

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 440 aa

Average Mass: 49.145 kDa

Monoisotopic Mass: 49.115 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Bartter syndrome, infantile, with sensorineural deafness (Barttin) 1. 96147131.00.1
--- cleavage 290 ---
--- cleavage 300 ---
Connexin 40 C-terminal domain 1. 40044079.00.0

3. Sequence Information

Fasta Sequence: SB0016.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

2 [sites]

Source Reference: [PubMed ID: 9208227] Lin JS, Fitzgerald S, Dong Y, Knight C, Donaldson P, Kistler J, Processing of the gap junction protein connexin50 in the ocular lens is accomplished by calpain. Eur J Cell Biol. 1997 Jun;73(2):141-9.

Cleavage sites (±10aa)


Glu290 Val

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)


Ser300 Ala

iTraq-117 Signal 3942.1 () for AKPFSQFEEK

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 8654111] Yang DI, Louis CF, Molecular cloning of sheep connexin49 and its identity with MP70. Curr Eye Res. 1996 Mar;15(3):307-14.