logo CaMPDB: Calpain for Modulatory Proteolysis Database

SB0019 : IL-1 [alpha], Interleukin 1 [alpha]

[ CaMP Format ]

* Basic Information

OrganismHomo sapiens (human)
Protein Namesinterleukin-1 alpha proprotein [Homo sapiens]; interleukin-1 alpha proprotein; preinterleukin 1 alpha; hematopoietin-1; interleukin-1 alpha; pro-interleukin-1-alpha; IL-1 alpha; Interleukin-1 alpha; Hematopoietin-1
Gene NamesIL1A; IL1F1; interleukin 1, alpha
Gene Locus2q14; chromosome 2
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_000566 NM_000575 3552 P01583 147760 HGNC:5991 N/A hsa:3552

* Information From OMIM

Description: IL1A is 1 of 2 structurally distinct forms of IL1, the other being IL1B (OMIM:147720). The IL1A and IL1B proteins are synthesized by a variety of cell types, including activated macrophages, keratinocytes, stimulated B lymphocytes, and fibroblasts, and are potent mediators of inflammation and immunity (Lord et al., 1991).

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* Structure Information

1. Primary Information

Length: 271 aa

Average Mass: 30.606 kDa

Monoisotopic Mass: 30.587 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Interleukin-1 propeptide 1. 11091.02.3
--- cleavage 118 ---
Interleukin-1 / 18 1. 1572663.00.0

3. Sequence Information

Fasta Sequence: SB0019.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1ITA (Model; -; A=121-271), 2ILA (X-ray; 230 A; A=117-271), 2KKI (NMR; -; A=121-271), 2L5X (NMR; -; A/D=121-271)

* Cleavage Information

1 [sites] cleaved by Calpain 1

Source Reference: [PubMed ID: 2115174] Kobayashi Y, Yamamoto K, Saido T, Kawasaki H, Oppenheim JJ, Matsushima K, Identification of calcium-activated neutral protease as a processing enzyme of human interleukin 1 alpha. Proc Natl Acad Sci U S A. 1990 Jul;87(14):5548-52.

Cleavage sites (±10aa)


Phe118 Leu

iTraq-117 Signal 5847.2 () for IKPRSAPFSF

iTraq-117 Signal 22261.8 () for LSNVKYNFMR

iTraq-117 Signal 6555.0 () for NVKYNFMR

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 24613844] Kwon MJ, Hong E, Choi Y, Kang DH, Oh ES, Interleukin-1alpha promotes extracellular shedding of syndecan-2 via induction of matrix metalloproteinase-7 expression. Biochem Biophys Res Commun. 2014 Apr 4;446(2):487-92. doi:

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