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SB0024 : Protein tyrosine phosphatase, receptor type, N

[ CaMP Format ]

* Basic Information

OrganismHomo sapiens (human)
Protein Namesreceptor-type tyrosine-protein phosphatase-like N isoform 1 precursor [Homo sapiens]; receptor-type tyrosine-protein phosphatase-like N isoform 1 precursor; islet cell antigen 512; islet cell autoantigen 3; protein tyrosine phosphatase-like N; islet cell antigen 2; ICA 512; PTP IA-2; Receptor-type tyrosine-protein phosphatase-like N; R-PTP-N; Islet cell antigen 512; Islet cell autoantigen 3
Gene NamesPTPRN; ICA3, ICA512; ICA3; ICA512; protein tyrosine phosphatase, receptor type, N
Gene Locus2q35-q36.1; chromosome 2
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_002837 NM_002846 5798 Q16849 601773 HGNC:9676 03466 hsa:5798

* Information From OMIM

Text: For general information about protein-tyrosine phosphatases (PTPases), see PTPRA (OMIM:176884).

* Structure Information

1. Primary Information

Length: 979 aa

Average Mass: 105.846 kDa

Monoisotopic Mass: 105.781 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
RESP18 domain 1. 601551.00.8
RESP18 domain 2. 33535814.00.1
Protein-tyrosine phosphatase receptor IA-2 1. 4695571.00.0
--- cleavage 608 ---
--- cleavage 658 ---
Dual specificity phosphatase, catalytic domain 1. 89295464.00.0

3. Sequence Information

Fasta Sequence: SB0024.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 2I1Y (X-ray; 223 A; A/B=681-979), 2QT7 (X-ray; 130 A; A/B=468-558), 3N01 (X-ray; 130 A; A/B=470-558), 3N4W (X-ray; 145 A; A/B=470-558), 3NG8 (X-ray; 135 A; A/B=470-558), 3NP5 (X-ray; 180 A; A/B/C/D=470-558)

* Cleavage Information

2 [sites] cleaved by Calpain 1

Source Reference: [PubMed ID: 11483505] Ort T, Voronov S, Guo J, Zawalich K, Froehner SC, Zawalich W, Solimena M, Dephosphorylation of beta2-syntrophin and Ca2+/mu-calpain-mediated cleavage of ICA512 upon stimulation of insulin secretion. EMBO J. 2001 Aug 1;20(15):4013-23.

Cleavage sites (±10aa)


Asp608 Lys

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)


Ser658 Ser

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 23396399] Long AE, Gillespie KM, Aitken RJ, Goode JC, Bingley PJ, Williams AJ, Humoral responses to islet antigen-2 and zinc transporter 8 are attenuated in patients carrying HLA-A*24 alleles at the onset of type 1 diabetes. Diabetes. 2013 Jun;62(6):2067-71. doi: 10.2337/db12-1468. Epub 2013 Feb 8.

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