logo CaMPDB: Calpain for Modulatory Proteolysis Database

SB0026 : BAX, BCL2-associated X protein

[ CaMP Format ]

* Basic Information

OrganismHomo sapiens (human)
Protein Namesapoptosis regulator BAX isoform alpha [Homo sapiens]; apoptosis regulator BAX isoform alpha; apoptosis regulator BAX; bcl2-L-4; bcl-2-like protein 4; BCL2-associated X protein omega; Baxdelta2G9; Baxdelta2omega; Baxdelta2G9omega; Apoptosis regulator BAX; Bcl-2-like protein 4; Bcl2-L-4
Gene NamesBAX; BCL2L4; BCL2-associated X protein
Gene Locus19q13.3-q13.4; chromosome 19
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_620116 NM_138761 581 Q07812 600040 HGNC:959 02498 hsa:581

* Information From OMIM

Description: The proapoptotic BAX protein induces cell death by acting on mitochondria.

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* Structure Information

1. Primary Information

Length: 192 aa

Average Mass: 21.184 kDa

Monoisotopic Mass: 21.171 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
--- cleavage 28 ---
Apoptosis regulator proteins, Bcl-2 family 1. 631581.00.1

3. Sequence Information

Fasta Sequence: SB0026.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1F16 (NMR; -; A=1-192), 2G5B (X-ray; 230 A; I/J/K/L=13-19), 2K7W (NMR; -; A=1-192), 2LR1 (NMR; -; A=1-192), 3PK1 (X-ray; 249 A; B/D=48-81), 3PL7 (X-ray; 261 A; C=48-81), 4BD2 (X-ray; 221 A; A=1-171), 4BD6 (X-ray; 249 A; A=1-171, C=48-81), 4BD7 (X-ray; 280 A; A/B/C/D=1-171), 4BD8 (X-ray; 222 A; A/B/C/D=1-171), 4BDU (X-ray; 300 A; A/B/C/D=53-128)

* Cleavage Information

1 [sites] cleaved by Calpain 1 or 2

Source Reference: [PubMed ID: 12490315] Toyota H, Yanase N, Yoshimoto T, Moriyama M, Sudo T, Mizuguchi J, Calpain-induced Bax-cleavage product is a more potent inducer of apoptotic cell death than wild-type Bax. Cancer Lett. 2003 Jan 28;189(2):221-30.

Cleavage sites (±10aa)


Gln28 Gly

iTraq-117 Signal 6932.5 () for GFIQDRAGRM

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 24680709] Li X, Zeng X, Sun J, Li H, Wu P, Fung KP, Liu F, Imperatorin induces Mcl-1 degradation to cooperatively trigger Bax translocation and Bak activation to suppress drug-resistant human hepatoma. Cancer Lett. 2014 Jun 28;348(1-2):146-55. doi: 10.1016/j.canlet.2014.03.017. Epub

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