logo CaMPDB: Calpain for Modulatory Proteolysis Database

SB0033 : Myosin 5A, heavy chain 12

[ CaMP Format ]

* Basic Information

OrganismGallus gallus (chicken)
Protein Namesunconventional myosin-Va [Gallus gallus]; unconventional myosin-Va; dilute myosin heavy chain, non-muscle; myosin heavy chain P190; myosin 5A; myosin I heavy chain isoform; myosin-Va; myosin VA (heavy polypeptide 12, myoxin); myosin VA (heavy chain 12, myosin); myosin, heavy polypeptide kinase; Unconventional myosin-Va; Dilute myosin heavy chain, non-muscle; Myosin heavy chain p190; Myosin-V
Gene NamesMYO5A; myosin VA (heavy chain 12, myoxin)
Gene Locus10; chromosome 10
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_990631 NM_205300 396237 Q02440 N/A N/A N/A gga:396237

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 1829 aa

Average Mass: 212.380 kDa

Monoisotopic Mass: 212.248 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Myosin N-terminal SH3-like domain 1. 12293.00.1
AAA ATPase domain 1. 14617915.00.0
Helix-turn-helix domain 1. 3073203.00.0
DIL domain 1. 78182324.00.2
IQ calmodulin-binding motif 1. 8398591.00.1
IQ calmodulin-binding motif 2. 8678844.00.2
Myosin head (motor domain) 1. 9041064204.07.4
--- cleavage 1140 ---
AAA ATPase domain 2. 1176121695.00.4
AAA ATPase domain 3. 13481381101.00.6
Helix-turn-helix domain 2. 1672170615.00.0
Helix-turn-helix domain 3. 172317346.00.0

3. Sequence Information

Fasta Sequence: SB0033.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1OE9 (X-ray; 205 A; A=1-792), 1W7I (X-ray; 300 A; A=1-792), 1W7J (X-ray; 200 A; A=1-792), 1W8J (X-ray; 270 A; A/B/C/D=1-766), 2DFS (EM; 2400 A; A/M=1-1080)

* Cleavage Information

1 [sites] cleaved by Calpain 1 or 2

Source Reference: [PubMed ID: 8663447] Nascimento AA, Cheney RE, Tauhata SB, Larson RE, Mooseker MS, Enzymatic characterization and functional domain mapping of brain myosin-V. J Biol Chem. 1996 Jul 19;271(29):17561-9.

Cleavage sites (±10aa)


Arg1140 Met

iTraq-117 Signal 2381.1 () for MEEPSEKKAP

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 24302658] Kanno TY, Espreafico EM, Yan CY, Role of myosin Va in neuritogenesis of chick dorsal root ganglia nociceptive neurons. Cell Biol Int. 2014 Mar;38(3):388-94. doi: 10.1002/cbin.10210. Epub 2013 Dec 3.

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