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SB0035 : G-protein [gamma]-12 subunit

[ CaMP Format ]

* Basic Information

OrganismHomo sapiens (human)
Protein Namesguanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 precursor [Homo sapiens]; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 precursor; G-protein gamma-12 subunit; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12; Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
Gene NamesGNG12; guanine nucleotide binding protein (G protein), gamma 12
Gene Locus1p31.3; chromosome 1
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_061329 NM_018841 55970 Q9UBI6 615405 HGNC:19663 13592 hsa:55970

* Information From OMIM

Description: G proteins, which are involved in receptor-mediated cell signaling, are heterotrimers of alpha, beta, and gamma subunits. Alpha subunits confer receptor-dependent GTPase activity. The beta-gamma subcomplex is required for functional association of alpha subunits with receptors and exerts regulatory control over downstream effectors. Gamma subunits, such as GNG12, are thought to determine the functional specificity of the beta-gamma subcomplex (summary by Hurowitz et al., 2000).

* Structure Information

1. Primary Information

Length: 72 aa

Average Mass: 8.006 kDa

Monoisotopic Mass: 8.001 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
--- cleavage 4 ---
CP12 domain 1. 54620.00.1

3. Sequence Information

Fasta Sequence: SB0035.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites] cleaved by Calpain 1

Source Reference: [PubMed ID: 7493986] Morishita R, Nakayama H, Isobe T, Matsuda T, Hashimoto Y, Okano T, Fukada Y, Mizuno K, Ohno S, Kozawa O, et al., Primary structure of a gamma subunit of G protein, gamma 12, and its phosphorylation by protein kinase C. J Biol Chem. 1995 Dec 8;270(49):29469-75.

Cleavage sites (±10aa)


Lys4 Thr

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 19056867] Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA, Large-scale proteomics and phosphoproteomics of urinary exosomes. J Am Soc Nephrol. 2009 Feb;20(2):363-79. doi: 10.1681/ASN.2008040406. Epub 2008

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