logo CaMPDB: Calpain for Modulatory Proteolysis Database

SB0041 : Gonadotropin-releasing hormone 1

[ CaMP Format ]

* Basic Information

OrganismRattus norvegicus (Norway rat)
Protein Namesprogonadoliberin-1 precursor [Rattus norvegicus]; progonadoliberin-1 precursor; progonadoliberin-1; luteinizing hormone-releasing hormone; progonadoliberin I; gonadotropin releasing hormone 1; Progonadoliberin-1; Progonadoliberin I; Gonadoliberin-1; Gonadoliberin I; Gonadotropin-releasing hormone I; GnRH-I; Luliberin I; Luteinizing hormone-releasing hormone I; LH-RH I; Prolactin release-inhibiting factor 1; Prolactin release-inhibiting factor I
Gene NamesGnrh1; Gnrh; gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
Gene Locus15p12; chromosome 15
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_036899 NM_012767 25194 P07490 N/A N/A N/A rno:25194

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 92 aa

Average Mass: 10.500 kDa

Monoisotopic Mass: 10.493 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Gonadotropin-releasing hormone 1. 24331.03.2
--- cleavage 28 (inside Gonadotropin-releasing hormone 24..33) ---
--- cleavage 29 (inside Gonadotropin-releasing hormone 24..33) ---
Gonadotropin-releasing hormone 2. 66672.00.6

3. Sequence Information

Fasta Sequence: SB0041.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

2 [sites] cleaved by Calpain 1 and 2

Source Reference: [PubMed ID: 6092335] Sasaki T, Kikuchi T, Yumoto N, Yoshimura N, Murachi T, Comparative specificity and kinetic studies on porcine calpain I and calpain II with naturally occurring peptides and synthetic fluorogenic substrates. J Biol Chem. 1984 Oct 25;259(20):12489-94.

Cleavage sites (±10aa)


Tyr28 Gly

iTraq-117 Signal 3525.1 () for GLRPGGKRNT

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)


Gly29 Leu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 23736294] True C, Verma S, Grove KL, Smith MS, Cocaine- and amphetamine-regulated transcript is a potent stimulator of GnRH and kisspeptin cells and may contribute to negative energy balance-induced reproductive inhibition in females. Endocrinology. 2013 Aug;154(8):2821-32. doi: 10.1210/en.2013-1156. Epub 2013 Jun

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