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SB0044 : [beta]-COP, [beta]-subunit of coatomer protein complex

[ CaMP Format ]

* Basic Information

OrganismHomo sapiens (human)
Protein Namescoatomer subunit beta [Homo sapiens]; coatomer subunit beta; beta-cop; beta coat protein; beta-coat protein; Coatomer subunit beta; Beta-coat protein; Beta-COP
Gene NamesCOPB1; MSTP026; COPB; coatomer protein complex, subunit beta 1
Gene Locus11p15.2; chromosome 11
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_057535 NM_016451 1315 P53618 600959 HGNC:2231 02981 hsa:1315

* Information From OMIM

Function: Olivos-Glander et al. (1995) demonstrated that the protein deficient in oculocerebral renal syndrome (OMIM:300535), OCRL1, is localized to the Golgi complex by using a monoclonal antibody against the Golgi-specific coat protein, beta-COP.

* Structure Information

1. Primary Information

Length: 953 aa

Average Mass: 107.141 kDa

Monoisotopic Mass: 107.074 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Dos2-interacting transcription regulator of RNA-Pol-II 1. 3766119.00.0
non-SMC mitotic condensation complex subunit 1 1. 13115921.00.0
Dos2-interacting transcription regulator of RNA-Pol-II 2. 23526192.00.0
Dos2-interacting transcription regulator of RNA-Pol-II 3. 380450188.00.0
HEAT-like repeat 1. 4564745.00.0
--- cleavage 528 ---
HEAT repeats 1. 53756531.00.0
HEAT-like repeat 2. 57058914.00.0
non-SMC mitotic condensation complex subunit 1 2. 617652105.00.1
Coatomer beta C-terminal region 1. 6678071.00.3
Adaptin AP4 complex epsilon appendage platform 1. 8328771.00.0

3. Sequence Information

Fasta Sequence: SB0044.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites] cleaved by Calpain 1

Source Reference: [PubMed ID: 16476741] Hata S, Koyama S, Kawahara H, Doi N, Maeda T, Toyama-Sorimachi N, Abe K, Suzuki K, Sorimachi H, Stomach-specific calpain, nCL-2, localizes in mucus cells and proteolyzes the beta-subunit of coatomer complex, beta-COP. J Biol Chem. 2006 Apr 21;281(16):11214-24. Epub 2006 Feb 13.

Cleavage sites (±10aa)


Ser528 Ser

iTraq-117 Signal 8568.3 () for SSRPTKKEED

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 18556652] Burman JL, Bourbonniere L, Philie J, Stroh T, Dejgaard SY, Presley JF, McPherson PS, Scyl1, mutated in a recessive form of spinocerebellar neurodegeneration, regulates COPI-mediated retrograde traffic. J Biol Chem. 2008 Aug 15;283(33):22774-86. doi: 10.1074/jbc.M801869200. Epub 2008

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