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SB0045 : MBP, Myelin basic protein

[ CaMP Format ]

* Basic Information

OrganismBos taurus (cattle)
Protein NamesRecName: Full=Myelin basic protein; Short=MBP; AltName: Full=20 kDa microtubule-stabilizing protein; AltName: Full=Myelin A1 protein; Myelin basic protein; 20 kDa microtubule-stabilizing protein; Myelin A1 protein; MBP
Gene NamesMBP
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
P02687 N/A N/A P02687 N/A N/A N/A bta:

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 169 aa

Average Mass: 18.323 kDa

Monoisotopic Mass: 18.312 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Myelin basic protein 1. 131691.08.8
--- cleavage 16 (inside Myelin basic protein 13..169) ---
--- cleavage 68 (inside Myelin basic protein 13..169) ---
--- cleavage 93 (inside Myelin basic protein 13..169) ---
--- cleavage 96 (inside Myelin basic protein 13..169) ---

3. Sequence Information

Fasta Sequence: SB0045.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

4 [sites] cleaved by Calpain 2

Source Reference: [PubMed ID: 2472383] Tsubata T, Takahashi K, Limited proteolysis of bovine myelin basic protein by calcium-dependent proteinase from bovine spinal cord. J Biochem. 1989 Jan;105(1):23-8.

Cleavage sites (±10aa)


Ala16 Ser

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)


Gly68 Ser

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)


Val93 Thr

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)


Arg96 Thr

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 5096093] Eylar EH, Brostoff S, Hashim G, Caccam J, Burnett P, Basic A1 protein of the myelin membrane. The complete amino acid sequence. J Biol Chem. 1971 Sep 25;246(18):5770-84.

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