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SB0048 : Annexin I

[ CaMP Format ]

* Basic Information

OrganismHomo sapiens (human)
Protein Namesannexin A1 [Homo sapiens]; annexin A1; annexin I (lipocortin I); annexin-1; calpactin-2; calpactin II; chromobindin-9; phospholipase A2 inhibitory protein; Annexin A1; Annexin I; Annexin-1; Calpactin II; Calpactin-2; Chromobindin-9; Lipocortin I; Phospholipase A2 inhibitory protein; p35
Gene NamesANXA1; ANX1, LPC1; ANX1; LPC1; annexin A1
Gene Locus9q21.13; chromosome 9
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_000691 NM_000700 301 P04083 151690 HGNC:533 01060 hsa:301

* Information From OMIM

Function: Walther et al. (2000) showed that ANXA1 acts through the formyl peptide receptor (FPR; OMIM:136537) on human neutrophils. Peptides derived from the unique N-terminal domain of ANXA1 serve as FPR ligands and trigger different signaling pathways in a dose-dependent manner. Lower peptide concentrations possibly found in inflammatory situations elicit Ca(2+) transients without fully activating the mitogen-activated protein kinase pathway. This causes a specific inhibition of the transendothelial migration of neutrophils and a desensitization of neutrophils toward a chemoattractant challenge. These findings identified ANXA1 peptides as novel, endogenous FPR ligands and established a mechanistic basis of ANXA1-mediated antiinflammatory effects.

* Structure Information

1. Primary Information

Length: 346 aa

Average Mass: 38.714 kDa

Monoisotopic Mass: 38.690 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
--- cleavage 26 ---
Myb DNA-binding like 1. 5010318.00.0
Myb DNA-binding like 2. 12515121.00.0
Myb DNA-binding like 3. 21326325.00.0
Myb DNA-binding like 4. 28430521.00.0

3. Sequence Information

Fasta Sequence: SB0048.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1AIN (X-ray; 250 A; A=33-346), 1BO9 (NMR; -; A=41-113), 1QLS (X-ray; 230 A; D=2-12)

* Cleavage Information

1 [sites] cleaved by Calpain 1

Source Reference: [PubMed ID: 2540167] Ando Y, Imamura S, Hong YM, Owada MK, Kakunaga T, Kannagi R, Enhancement of calcium sensitivity of lipocortin I in phospholipid binding induced by limited proteolysis and phosphorylation at the amino terminus as analyzed by phospholipid affinity column chromatography. J Biol Chem. 1989 Apr 25;264(12):6948-55.

Cleavage sites (±10aa)


Lys26 Ser

iTraq-117 Signal 721.2 () for EEQEYVQTVK

iTraq-117 Signal 2656.4 () for SSKGGPGSAV

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 24480285] Yu CJ, Ko CJ, Hsieh CH, Chien CT, Huang LH, Lee CW, Jiang CC, Proteomic analysis of osteoarthritic chondrocyte reveals the hyaluronic acid-regulated proteins involved in chondroprotective effect under oxidative stress. J Proteomics. 2014 Mar 17;99:40-53. doi: 10.1016/j.jprot.2014.01.016. Epub 2014

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