logo CaMPDB: Calpain for Modulatory Proteolysis Database

SB0049 : [beta]-Neoendorphin-dynorphin

[ CaMP Format ]

* Basic Information

OrganismMus musculus (house mouse)
Protein Namesproenkephalin-B preproprotein [Mus musculus]; proenkephalin-B preproprotein; proenkephalin-B; preprodynorphin; beta-neoendorphin-dynorphin; alpha-neoendorphin; leu-enkephalin; big dynorphin; dynorphin A(1-17); dynorphin A(1-13); dynorphin A(1-8); leumorphin; rimorphin
Gene NamesPdyn; prodynorphin
Gene Locus2 63.19 cM; chromosome 2
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_061351 NM_018863 18610 N/A N/A N/A N/A N/A

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 248 aa

Average Mass: 28.009 kDa

Monoisotopic Mass: 27.992 kDa

2. Domain Information

Annotated Domains: Not Available.

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Vertebrate endogenous opioids neuropeptide 1. 22661.03.4

3. Sequence Information

Fasta Sequence: SB0049.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

2 [sites] cleaved by Calpain 1 and 2

Source Reference: [PubMed ID: 6092335] Sasaki T, Kikuchi T, Yumoto N, Yoshimura N, Murachi T, Comparative specificity and kinetic studies on porcine calpain I and calpain II with naturally occurring peptides and synthetic fluorogenic substrates. J Biol Chem. 1984 Oct 25;259(20):12489-94.

Cleavage sites (±10aa)


Arg207 Arg

iTraq-117 Signal 14116.5 () for LYKRYGGFLR

iTraq-117 Signal 7582.7 () for RIRPKLK

iTraq-117 Signal 6159.0 () for RIRPKLKWDN

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)


Lys214 Trp

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 24487620] Krashes MJ, Shah BP, Madara JC, Olson DP, Strochlic DE, Garfield AS, Vong L, Pei H, Watabe-Uchida M, Uchida N, Liberles SD, Lowell BB, An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger. Nature. 2014 Mar 13;507(7491):238-42. doi: 10.1038/nature12956. Epub 2014 Feb 2.

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