logo CaMPDB: Calpain for Modulatory Proteolysis Database

SB0056 : Plasma membrane calcium ATPase 2

[ CaMP Format ]

* Basic Information

OrganismHomo sapiens (human)
Protein Namesplasma membrane calcium-transporting ATPase 2 isoform 1 [Homo sapiens]; plasma membrane calcium-transporting ATPase 2 isoform 1; plasma membrane Ca2+ pump 2; plasma membrane calcium pump; plasma membrane calcium-transporting ATPase 2; plasma membrane calcium ATPase; plasma membrane Ca(2+)-ATPase; Plasma membrane calcium-transporting ATPase 2; PMCA2;; Plasma membrane calcium ATPase isoform 2; Plasma membrane calcium pump isoform 2
Gene NamesATP2B2; PMCA2; ATPase, Ca++ transporting, plasma membrane 2
Gene Locus3p25.3; chromosome 3
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_001001331 NM_001001331 491 Q01814 108733 HGNC:815 00160 hsa:491

* Information From OMIM

Description: The Ca(2+)-ATPases are a family of plasma membrane pumps encoded by at least 4 genes: ATP2B1 (OMIM:108731) on chromosome 12q21; ATP2B2; ATP2B3 (OMIM:300014) on Xq28; and ATP2B4 (OMIM:108732) on 1q25.

» More (1)

* Structure Information

1. Primary Information

Length: 1243 aa

Average Mass: 136.875 kDa

Monoisotopic Mass: 136.789 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Cation transporter/ATPase, N-terminus 1. 511184.00.0
E1-E2 ATPase 1. 1572913.01.0
E1-E2 ATPase 2. 379488133.00.7
Cation transport ATPase (P-type) 1. 5446373.00.0
haloacid dehalogenase-like hydrolase 1. 71074717.00.1
haloacid dehalogenase-like hydrolase 2. 794864186.00.5
E1-E2 ATPase 3. 875906144.00.4
Integral membrane protein DUF106 1. 94896988.00.1
--- cleavage 1124 ---
Plasma membrane calcium transporter ATPase C terminal 1. 112611771.00.1
--- cleavage 1135 (inside Plasma membrane calcium transporter ATPase C terminal 1126..1177) ---

3. Sequence Information

Fasta Sequence: SB0056.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

2 [sites] cleaved by Calpain 1

Source Reference: [PubMed ID: 2542272] James P, Vorherr T, Krebs J, Morelli A, Castello G, McCormick DJ, Penniston JT, De Flora A, Carafoli E, Modulation of erythrocyte Ca2+-ATPase by selective calpain cleavage of the calmodulin-binding domain. J Biol Chem. 1989 May 15;264(14):8289-96.

Cleavage sites (±10aa)


Arg1124 Arg

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)


Asn1135 Arg

iTraq-117 Signal 8790.4 () for RIQTQIRVVK

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 23620727] Yang W, Liu J, Zheng F, Jia M, Zhao L, Lu T, Ruan Y, Zhang J, Yue W, Zhang D, Wang L, The evidence for association of ATP2B2 polymorphisms with autism in Chinese Han population. PLoS One. 2013 Apr 19;8(4):e61021. doi: 10.1371/journal.pone.0061021. Print 2013.

» More (10)