logo CaMPDB: Calpain for Modulatory Proteolysis Database

SB0064 : c-fos

[ CaMP Format ]

* Basic Information

OrganismRattus norvegicus (Norway rat)
Protein Namesproto-oncogene c-Fos [Rattus norvegicus]; proto-oncogene c-Fos; c-fos oncogene; v-fos FBJ murine osteosarcoma viral oncogene homolog; proto-oncogene cFOS; Proto-oncogene c-Fos; Cellular oncogene fos
Gene NamesFos; FBJ osteosarcoma oncogene
Gene Locus6q31; chromosome 6
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_071533 NM_022197 314322 P12841 N/A N/A N/A rno:314322

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 380 aa

Average Mass: 40.926 kDa

Monoisotopic Mass: 40.901 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
--- cleavage 90 ---
Transmembrane protein 1. 126191482.08.5

3. Sequence Information

Fasta Sequence: SB0064.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites] cleaved by Calpain 2

Source Reference: [PubMed ID: 10600648] Pariat M, Salvat C, Bebien M, Brockly F, Altieri E, Carillo S, Jariel-Encontre I, Piechaczyk M, The sensitivity of c-Jun and c-Fos proteins to calpains depends on conformational determinants of the monomers and not on formation of dimers. Biochem J. 2000 Jan 1;345 Pt 1:129-38.

Cleavage sites (±10aa)


Thr90 Arg

iTraq-117 Signal 28697.1 () for RAPHPYGLPT

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 24049115] Miller RL, Wang MH, Gray PA, Salkoff LB, Loewy AD, ENaC-expressing neurons in the sensory circumventricular organs become c-Fos activated following systemic sodium changes. Am J Physiol Regul Integr Comp Physiol. 2013 Nov 15;305(10):R1141-52. doi:

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