logo CaMPDB: Calpain for Modulatory Proteolysis Database

SB0065 : ADP-ribosyltransferase (NAD+) poly(ADP-ribose) polymerase

[ CaMP Format ]

* Basic Information

OrganismBos taurus (cattle)
Protein Namespoly [ADP-ribose] polymerase 1 [Bos taurus]; poly [ADP-ribose] polymerase 1; poly (ADP-ribose) polymerase family, member 1; poly(ADP-ribose) synthetase; ADP-ribosyltransferase (NAD+) poly (ADP-ribose) polymerase); PARP-1; ADP-ribosyltransferase diphtheria toxin-like 1; poly[ADP-ribose] synthetase 1; NAD(+) ADP-ribosyltransferase 1; ADPRT 1; poly[ADP-ribose] synthase 1; Poly [ADP-ribose] polymerase 1;; ARTD1; Poly[ADP-ribose] synthase 1
Gene NamesPARP1; ADPRT; poly (ADP-ribose) polymerase 1
Gene Locus16; chromosome 16
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_777176 NM_174751 286764 P18493 N/A N/A N/A bta:286764

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 1016 aa

Average Mass: 113.485 kDa

Monoisotopic Mass: 113.415 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
PADR1 (NUC008) domain 1. 202615.00.7
PADR1 (NUC008) domain 2. 12714815.00.1
Poly(ADP-ribose) polymerase catalytic domain 1. 21425113.00.2
Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region 1. 32235941.00.3
--- cleavage 384 ---
Poly(ADP-ribose) polymerase, regulatory domain 1. 39540731.00.4
--- cleavage 480 ---
--- cleavage 502 ---
WGR domain 1. 5566322.00.2
--- cleavage 658 ---
Bacterial protein of unknown function (DUF948) 1. 75377052.00.0
Poly(ADP-ribose) polymerase catalytic domain 2. 79910091.00.0

3. Sequence Information

Fasta Sequence: SB0065.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

4 [sites] cleaved by Calpain 1

Source Reference: [PubMed ID: 9074620] Buki KG, Bauer PI, Kun E, Isolation and identification of a proteinase from calf thymus that cleaves poly(ADP-ribose) polymerase and histone H1. Biochim Biophys Acta. 1997 Mar 7;1338(1):100-6.

Cleavage sites (±10aa)


His384 Ser

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)


Leu480 Ser

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)


Gly502 Ala

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)


Thr658 Val

iTraq-117 Signal 1517.9 () for KKLTVNPGTK

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 23272074] Wu B, Liu HL, Zhang S, Dong XR, Wu G, Lack of an association between two BER gene polymorphisms and breast cancer risk: a meta-analysis. PLoS One. 2012;7(12):e50857. doi: 10.1371/journal.pone.0050857. Epub 2012 Dec 14.

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