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SB0066 : Troponin T2, cardiac, TnTc

[ CaMP Format ]

* Basic Information

OrganismMus musculus (house mouse)
Protein Namestroponin T, cardiac muscle isoform f [Mus musculus]; troponin T, cardiac muscle isoform f; troponin T, cardiac muscle; tnTc; cardiac muscle troponin T; cardiac TnT; Troponin T, cardiac muscle; TnTc; Cardiac muscle troponin T; cTnT
Gene NamesTnnt2; troponin T2, cardiac
Gene Locus1 59.32 cM; chromosome 1
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_035749 NM_011619 21956 P50752 N/A N/A N/A mmu:21956

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 288 aa

Average Mass: 34.219 kDa

Monoisotopic Mass: 34.199 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Troponin 1. 72416.03.8
--- cleavage 71 ---
Protein of unknown function (DUF1800) 1. 14826958.07.8

3. Sequence Information

Fasta Sequence: SB0066.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites] cleaved by Calpain 1

Source Reference: [PubMed ID: 16981728] Zhang Z, Biesiadecki BJ, Jin JP, Selective deletion of the NH2-terminal variable region of cardiac troponin T in ischemia reperfusion by myofibril-associated mu-calpain cleavage. Biochemistry. 2006 Sep 26;45(38):11681-94.

Cleavage sites (±10aa)


Arg71 Leu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 23897817] Kobayashi M, Debold EP, Turner MA, Kobayashi T, Cardiac muscle activation blunted by a mutation to the regulatory component, troponin T. J Biol Chem. 2013 Sep 6;288(36):26335-49. doi: 10.1074/jbc.M113.494096. Epub 2013

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