logo CaMPDB: Calpain for Modulatory Proteolysis Database

SB0068 : Crystallin, [beta]B3

[ CaMP Format ]

* Basic Information

OrganismBos taurus (cattle)
Protein Namesbeta-crystallin B3 [Bos taurus]; beta-crystallin B3; beta-B3 crystallin; Beta-crystallin B3; Beta-B3 crystallin; Beta-crystallin B3, N-terminally processed
Gene NamesCRYBB3; crystallin, beta B3
Gene Locus17; chromosome 17
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_776952 NM_174527 282206 P19141 N/A N/A N/A bta:282206

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 211 aa

Average Mass: 24.328 kDa

Monoisotopic Mass: 24.313 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
--- cleavage 5 ---
--- cleavage 10 ---
Beta/Gamma crystallin 1. 251061.00.0
Beta/Gamma crystallin 2. 1151971.00.1

3. Sequence Information

Fasta Sequence: SB0068.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

2 [sites] cleaved by Calpain 2

Source Reference: [PubMed ID: 9485487] Shih M, Lampi KJ, Shearer TR, David LL, Cleavage of beta crystallins during maturation of bovine lens. Mol Vis. 1998 Feb 27;4:4.

Cleavage sites (±10aa)


His5 Ser

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)


Gln10 Ala

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 19206113] Diemer H, Atmanene C, Sanglier S, Morrissey B, Van Dorsselaer A, Downard KM, Detection and structural features of the betaB2-B3-crystallin heterodimer by radical probe mass spectrometry (RP-MS). J Mass Spectrom. 2009 May;44(5):803-12. doi: 10.1002/jms.1560.

» More (3)