logo CaMPDB: Calpain for Modulatory Proteolysis Database

SB0069 : Crystallin, [beta]A1/A3

[ CaMP Format ]

* Basic Information

OrganismBos taurus (cattle)
Protein Namesbeta-crystallin A3 [Bos taurus]; beta-crystallin A3; beta A3 crystallin; lens structural protein; Beta-crystallin A3; Beta-crystallin A3, isoform A1, Delta4 form; Beta-crystallin A3, isoform A1, Delta7 form; Beta-crystallin A3, isoform A1, Delta8 form
Gene NamesCRYBA1; crystallin, beta A1
Gene Locus19q15; chromosome 19
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_776948 NM_174523 282202 P11843 N/A N/A N/A bta:282202

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 215 aa

Average Mass: 25.130 kDa

Monoisotopic Mass: 25.114 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
--- cleavage 11 ---
--- cleavage 17 ---
Protein of unknown function (DUF2914) 1. 204933.00.0
Protein of unknown function (DUF2914) 2. 17318125.00.2
Protein of unknown function (DUF2914) 3. 19220025.00.1

3. Sequence Information

Fasta Sequence: SB0069.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

2 [sites] cleaved by Calpain 2

Source Reference: [PubMed ID: 9485487] Shih M, Lampi KJ, Shearer TR, David LL, Cleavage of beta crystallins during maturation of bovine lens. Mol Vis. 1998 Feb 27;4:4.

Cleavage sites (±10aa)


Lys11 Ser

iTraq-117 Signal 423.5 () for ETQTVQQELK

iTraq-117 Signal 565.0 () for SLPTTKMAQT

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)


Lys17 Met

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 19393038] Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Marcais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL, A whole-genome assembly of the domestic cow, Bos taurus. Genome Biol. 2009;10(4):R42. doi: 10.1186/gb-2009-10-4-r42. Epub 2009 Apr 24.

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