logo CaMPDB: Calpain for Modulatory Proteolysis Database

SB0071 : [alpha]-Actin-1

[ CaMP Format ]

* Basic Information

OrganismHomo sapiens (human)
Protein Namesactin, alpha skeletal muscle [Homo sapiens]; actin, alpha skeletal muscle; nemaline myopathy type 3; Actin, alpha skeletal muscle; Alpha-actin-1
Gene NamesACTA1; ACTA; actin, alpha 1, skeletal muscle
Gene Locus1q42.13; chromosome 1
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_001091 NM_001100 58 P68133 102610 HGNC:129 00030 hsa:58

* Information From OMIM

Description: The ACTA1 gene encodes skeletal muscle alpha-actin, the principal actin isoform in adult skeletal muscle, which forms the core of the thin filament of the sarcomere where it interacts with a variety of proteins to produce the force for muscle contraction (Laing et al., 2009).

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* Structure Information

1. Primary Information

Length: 377 aa

Average Mass: 42.051 kDa

Monoisotopic Mass: 42.024 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Actin 1. 53772.00.0
--- cleavage 39 (inside Actin 5..377) ---

3. Sequence Information

Fasta Sequence: SB0071.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1T44 (X-ray; 200 A; A=8-377)

* Cleavage Information

1 [sites] cleaved by Calpain 1 and/or 2

Source Reference: [PubMed ID: 9472000] Villa PG, Henzel WJ, Sensenbrenner M, Henderson CE, Pettmann B, Calpain inhibitors, but not caspase inhibitors, prevent actin proteolysis and DNA fragmentation during apoptosis. J Cell Sci. 1998 Mar;111 ( Pt 6):713-22.

Cleavage sites (±10aa)


Arg39 Pro

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 24313005] Sudo A, Hayashi Y, Sano H, Kawamura N, Nishino I, Nonaka I, [Sibling cases of severe infantile form of nemaline myopathy with ACTA1-gene mutation]. No To Hattatsu. 2013 Nov;45(6):452-6.

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