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SB0072 : Glutamate receptor, ionotropic, NMDA 2A

[ CaMP Format ]

* Basic Information

OrganismRattus norvegicus (Norway rat)
Protein Namesglutamate receptor ionotropic, NMDA 2A precursor [Rattus norvegicus]; glutamate receptor ionotropic, NMDA 2A precursor; glutamate [NMDA] receptor subunit epsilon-1; glutamate receptor ionotropic, NMDA 2A; N-methyl-D-aspartate receptor subunit 2A; N-methyl D-aspartate receptor subtype 2A
Gene NamesGrin2a; glutamate receptor, ionotropic, N-methyl D-aspartate 2A
Gene Locus10q11; chromosome 10
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_036705 NM_012573 24409 N/A N/A N/A N/A N/A

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 1464 aa

Average Mass: 165.481 kDa

Monoisotopic Mass: 165.377 kDa

2. Domain Information

Annotated Domains: Not Available.

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Receptor family ligand binding region 1. 10926563.00.1
Bacterial extracellular solute-binding proteins, family 3 1. 45779722.00.0
N-methyl D-aspartate receptor 2B3 C-terminus 1. 83914641.031.1
--- cleavage 1278 (inside N-methyl D-aspartate receptor 2B3 C-terminus 839..1464) ---
--- cleavage 1329 (inside N-methyl D-aspartate receptor 2B3 C-terminus 839..1464) ---

3. Sequence Information

Fasta Sequence: SB0072.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

2 [sites] cleaved by Calpain 1

Source Reference: [PubMed ID: 11553682] Guttmann RP, Baker DL, Seifert KM, Cohen AS, Coulter DA, Lynch DR, Specific proteolysis of the NR2 subunit at multiple sites by calpain. J Neurochem. 2001 Sep;78(5):1083-93.

Cleavage sites (±10aa)


Gln1278 Phe

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)


Phe1329 Ser

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 24607230] Hansen KB, Ogden KK, Yuan H, Traynelis SF, Distinct functional and pharmacological properties of Triheteromeric GluN1/GluN2A/GluN2B NMDA receptors. Neuron. 2014 Mar 5;81(5):1084-96. doi: 10.1016/j.neuron.2014.01.035.

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