logo CaMPDB: Calpain for Modulatory Proteolysis Database

SB0082 : Crystallin, [beta]B2

[ CaMP Format ]

* Basic Information

OrganismBos taurus (cattle)
Protein Namesbeta-crystallin B2 [Bos taurus]; beta-crystallin B2; beta-B2 crystallin; beta-crystallin Bp; Beta-crystallin B2; Beta-B2 crystallin; Beta-crystallin Bp
Gene NamesCRYBB2; crystallin, beta B2
Gene Locus17; chromosome 17
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_777232 NM_174807 287011 P02522 N/A N/A N/A bta:287011

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 205 aa

Average Mass: 23.298 kDa

Monoisotopic Mass: 23.283 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
--- cleavage 8 ---
Peptidase inhibitor family I36 1. 219612.00.0
Peptidase inhibitor family I36 2. 1081919.00.0

3. Sequence Information

Fasta Sequence: SB0082.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1BLB (X-ray; 330 A; A/B/C/D=2-205), 2BB2 (X-ray; 210 A; A=15-195)

* Cleavage Information

1 [sites] cleaved by Calpain 2

Source Reference: [PubMed ID: 9485487] Shih M, Lampi KJ, Shearer TR, David LL, Cleavage of beta crystallins during maturation of bovine lens. Mol Vis. 1998 Feb 27;4:4.

Cleavage sites (±10aa)


Gln8 Ala

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 19206113] Diemer H, Atmanene C, Sanglier S, Morrissey B, Van Dorsselaer A, Downard KM, Detection and structural features of the betaB2-B3-crystallin heterodimer by radical probe mass spectrometry (RP-MS). J Mass Spectrom. 2009 May;44(5):803-12. doi: 10.1002/jms.1560.

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