logo CaMPDB: Calpain for Modulatory Proteolysis Database

SB0083 : p19INK4d, Cyclin-dependent kinase inhibitor 2D

[ CaMP Format ]

* Basic Information

OrganismHomo sapiens (human)
Protein Namescyclin-dependent kinase 4 inhibitor D [Homo sapiens]; cyclin-dependent kinase 4 inhibitor D; CDK inhibitor p19INK4d; cyclin-dependent kinase 4 inhibitor D p19; inhibitor of cyclin-dependent kinase 4d; cell cycle inhibitor, Nur77 associating protein; Cyclin-dependent kinase 4 inhibitor D; p19-INK4d
Gene NamesCDKN2D; cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
Gene Locus19p13; chromosome 19
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_001791 NM_001800 1032 P55273 600927 HGNC:1790 02957 hsa:1032

* Information From OMIM

Description: Cyclins are important in regulating the cell cycle through their formation of enzymatic complexes with various cyclin-dependent kinases. The D type cyclins complex with CDK4 (OMIM:123829) and CDK6 (OMIM:603368) to govern progression through the G1 phase of the cell cycle and later are involved with inactivating phosphorylation of the RB1 protein (OMIM:614041), which results in release of RB1-associated transcription factors that are needed for entry into S phase (Okuda et al., 1995). The activity of the cyclin D-dependent kinases is, in part, controlled by inhibitors such as the INK4 family, which includes INK4a (CDKN2A; OMIM:600160), 4b (CDKN2B; OMIM:600431), 4c (CDKN2C; OMIM:603369), and 4d (CDKN2D). INK4a has been shown to act by competing with CDK4 and CDK6 and functions as a tumor suppressor in a variety of cancers.

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* Structure Information

1. Primary Information

Length: 166 aa

Average Mass: 17.700 kDa

Monoisotopic Mass: 17.689 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Ankyrin repeats (many copies) 1. 154723.00.0
--- cleavage 25 (inside Ankyrin repeats (many copies) 15..47) ---
--- cleavage 29 (inside Ankyrin repeats (many copies) 15..47) ---
--- cleavage 47 (inside Ankyrin repeats (many copies) 15..47) ---
--- cleavage 47 ---
Ankyrin repeats (many copies) 2. 49949.00.0
--- cleavage 64 (inside Ankyrin repeats (many copies) 49..94) ---
--- cleavage 113 ---
--- cleavage 127 ---
Ankyrin repeats (many copies) 3. 13115126.00.0

3. Sequence Information

Fasta Sequence: SB0083.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1BD8 (X-ray; 180 A; A=7-162), 1BI8 (X-ray; 280 A; B/D=1-166)

* Cleavage Information

6 [sites] cleaved by Calpain 1

Source Reference: [PubMed ID: 16542156] Joy J, Nalabothula N, Ghosh M, Popp O, Jochum M, Machleidt W, Gil-Parrado S, Holak TA, Identification of calpain cleavage sites in the G1 cyclin-dependent kinase inhibitor p19(INK4d). Biol Chem. 2006 Mar;387(3):329-35.

Cleavage sites (±10aa)


Arg25 Arg

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)


His29 Arg

iTraq-117 Signal 623.5 () for DVQEVRRLLH

iTraq-117 Signal 5802.3 () for RELVHPDALN

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)


Gln47 Val

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)


Gly64 Ala

iTraq-117 Signal 302.2 () for AIALELLKQG

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)


Leu113 Ala

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)


Ala127 Ala

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 23536791] Lin S, Wang MJ, Tseng KY, Polypyrimidine tract-binding protein induces p19(Ink4d) expression and inhibits the proliferation of H1299 cells. PLoS One. 2013;8(3):e58227. doi: 10.1371/journal.pone.0058227. Epub 2013 Mar 11.

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