logo CaMPDB: Calpain for Modulatory Proteolysis Database

SB0086 : c-jun

[ CaMP Format ]

* Basic Information

OrganismRattus norvegicus (Norway rat)
Protein Namestranscription factor AP-1 [Rattus norvegicus]; transcription factor AP-1; AP1; activator protein 1; proto-oncogene c-jun; V-jun avian sarcoma virus 17 oncogene homolog; v-jun sarcoma virus 17 oncogene homolog; Avian sarcoma virus 17 (v-jun) oncogene homolog; Jun oncogene; Transcription factor AP-1; Activator protein 1; Proto-oncogene c-Jun
Gene NamesJun; Rjg-9; jun proto-oncogene
Gene Locus5q34.1; chromosome 5
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_068607 NM_021835 24516 P17325 N/A N/A N/A rno:24516

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 334 aa

Average Mass: 36.000 kDa

Monoisotopic Mass: 35.978 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
--- cleavage 42 ---
--- cleavage 62 ---
--- cleavage 90 ---
--- cleavage 164 ---
LMBR1-like membrane protein 1. 255322180.01.4

3. Sequence Information

Fasta Sequence: SB0086.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

4 [sites] cleaved by Calpain 2

Source Reference: [PubMed ID: 10600648] Pariat M, Salvat C, Bebien M, Brockly F, Altieri E, Carillo S, Jariel-Encontre I, Piechaczyk M, The sensitivity of c-Jun and c-Fos proteins to calpains depends on conformational determinants of the monomers and not on formation of dimers. Biochem J. 2000 Jan 1;345 Pt 1:129-38.

Cleavage sites (±10aa)


Leu42 Ala

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)


Thr62 Ser

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)


Thr90 Thr

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)


His164 Ser

iTraq-117 Signal 3055.6 () for GGGGYSASLH

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 24492282] Dorn C, Engelmann JC, Saugspier M, Koch A, Hartmann A, Muller M, Spang R, Bosserhoff A, Hellerbrand C, Increased expression of c-Jun in nonalcoholic fatty liver disease. Lab Invest. 2014 Apr;94(4):394-408. doi: 10.1038/labinvest.2014.3. Epub 2014 Feb

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