logo CaMPDB: Calpain for Modulatory Proteolysis Database

SB0088 : Crystallin, [beta]B1

[ CaMP Format ]

* Basic Information

OrganismRattus norvegicus (Norway rat)
Protein Namescrystallin, beta B1 [Rattus norvegicus]; crystallin, beta B1; Beta-crystallin B1; Beta-B1 crystallin; Beta-crystallin B1B
Gene NamesCrybb1; crystallin, beta B1
Gene Locus12; chromosome 12
GO FunctionGO:0005212 - structural constituent of eye lens [Evidence IDA]; GO:0005212 - structural constituent of eye lens [Evidence IEA]
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_037068 NM_012936 25421 P02523 N/A N/A N/A rno:25421

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 249 aa

Average Mass: 28.043 kDa

Monoisotopic Mass: 28.026 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
--- cleavage 49 ---
Peptidase inhibitor family I36 1. 571009.00.0
Beta/Gamma crystallin 1. 1011188.00.0
Peptidase inhibitor family I36 2. 1461858.00.1

3. Sequence Information

Fasta Sequence: SB0088.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites] cleaved by Calpain 2

Source Reference: [PubMed ID: 8405363] David LL, Shearer TR, Beta-crystallins insolubilized by calpain II in vitro contain cleavage sites similar to beta-crystallins insolubilized during cataract. FEBS Lett. 1993 Jun 21;324(3):265-70.

Cleavage sites (±10aa)


Gly49 Glu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 15060019] Kwitek AE, Gullings-Handley J, Yu J, Carlos DC, Orlebeke K, Nie J, Eckert J, Lemke A, Andrae JW, Bromberg S, Pasko D, Chen D, Scheetz TE, Casavant TL, Soares MB, Sheffield VC, Tonellato PJ, Jacob HJ, High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Genome Res. 2004 Apr;14(4):750-7.

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