logo CaMPDB: Calpain for Modulatory Proteolysis Database

SB0090 : Filamin A

[ CaMP Format ]

* Basic Information

OrganismHomo sapiens (human)
Protein Namesfilamin-A isoform 1 [Homo sapiens]; filamin-A isoform 1; actin binding protein 280; filamin-A; endothelial actin-binding protein; non-muscle filamin; filamin-1; alpha-filamin; Filamin-A; FLN-A; Actin-binding protein 280; ABP-280; Alpha-filamin; Endothelial actin-binding protein; Filamin-1; Non-muscle filamin
Gene NamesFLNA; FLN, FLN1; FLN; FLN1; filamin A, alpha
Gene LocusXq28; chromosome X
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_001447 NM_001456 2316 Q5HY53 300017 HGNC:3754 N/A hsa:2316

* Information From OMIM

Description: The FLNA gene encodes filamin A, a widely expressed 280-kD actin-binding protein that regulates reorganization of the actin cytoskeleton by interacting with integrins, transmembrane receptor complexes, and second messengers. Filamins crosslink actin filaments into orthogonal networks in the cytoplasm and participate in the anchoring of membrane proteins to the actin cytoskeleton. Remodeling of the cytoskeleton is central to the modulation of cell shape and migration (Maestrini et al., 1993; Fox et al., 1998).

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* Structure Information

1. Primary Information

Length: 2639 aa

Average Mass: 280.015 kDa

Monoisotopic Mass: 279.843 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
CAMSAP CH domain 1. 6111710.00.1
CAMSAP CH domain 2. 18420812.00.0
Rib/alpha-like repeat 1. 30533332.00.1
Domain of unknown function (DUF5060) 1. 33436052.00.1
Domain of unknown function (DUF5060) 2. 43646054.00.0
YtkA-like 1. 52355454.00.2
Domain of unknown function (DUF5060) 3. 63364762.00.0
Bacterial Ig-like domain (group 3) 1. 69575114.00.0
Domain of unknown function (DUF5060) 4. 82984755.00.0
Domain of unknown function (DUF5060) 5. 93094357.00.0
Domain of unknown function (DUF5060) 6. 1031104662.00.0
YtkA-like 2. 1117113764.00.0
Y_Y_Y domain 1. 1214123527.00.0
Domain of unknown function (DUF5060) 7. 1315133358.00.0
YtkA-like 3. 1397142656.00.0
Calponin homology (CH) domain 1. 1491151275.00.0
Domain of unknown function (DUF5060) 8. 1600161756.00.0
YtkA-like 4. 1675171439.00.0
--- cleavage 1761 ---
Domain of unknown function (DUF5060) 9. 1821183061.00.0
PapC N-terminal domain 1. 1919194126.00.0
Filamin/ABP280 repeat 1. 1980202749.00.0
Domain of unknown function (DUF5060) 10. 2095210761.00.0
Domain of unknown function (DUF5060) 11. 2185220755.00.0
YtkA-like 5. 2292230564.00.0
Domain of unknown function (DUF5060) 12. 2377239957.00.0
Domain of unknown function (DUF5060) 13. 2474248759.00.0
Y_Y_Y domain 2. 2607262430.00.0

3. Sequence Information

Fasta Sequence: SB0090.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 2AAV (NMR; -; A=1863-1956), 2BP3 (X-ray; 232 A; A/B=1863-1956), 2BRQ (X-ray; 210 A; A/B=2236-2329), 2J3S (X-ray; 250 A; A/B=2045-2329), 2JF1 (X-ray; 220 A; A=2236-2329), 2K3T (NMR; -; A=2427-2522), 2K7P (NMR; -; A=1772-1956), 2K7Q (NMR; -; A=1954-2141), 2MTP (NMR; -; A=2236-2330), 2W0P (X-ray; 190 A; A/B=2236-2329), 2WFN (X-ray; 320 A; A/B=1-278), 3CNK (X-ray; 165 A; A/B=2559-2647), 3HOC (X-ray; 230 A; A/B=2-269), 3HOP (X-ray; 230 A; A/B=2-269), 3HOR (X-ray; 270 A; A/B=2-269), 3ISW (X-ray; 280 A; A/B=2236-2329), 3RGH (X-ray; 244 A; A/B=1158-1252), 4M9P (X-ray; 172 A; A=478-766)

* Cleavage Information

1 [sites] cleaved by Calpain 1 or 2

Source Reference: [PubMed ID: 2391361] Gorlin JB, Yamin R, Egan S, Stewart M, Stossel TP, Kwiatkowski DJ, Hartwig JH, Human endothelial actin-binding protein (ABP-280, nonmuscle filamin): a molecular leaf spring. J Cell Biol. 1990 Sep;111(3):1089-105.

Cleavage sites (±10aa)


Gln1761 Thr

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 24403084] Noam Y, Ehrengruber MU, Koh A, Feyen P, Manders EM, Abbott GW, Wadman WJ, Baram TZ, Filamin A promotes dynamin-dependent internalization of hyperpolarization-activated cyclic nucleotide-gated type 1 (HCN1) channels and restricts Ih in hippocampal neurons. J Biol Chem. 2014 Feb 28;289(9):5889-903. doi: 10.1074/jbc.M113.522060. Epub 2014

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