logo CaMPDB: Calpain for Modulatory Proteolysis Database

SB0094 : Crystallin, [beta]B1

[ CaMP Format ]

* Basic Information

OrganismBos taurus (cattle)
Protein Namesput. beta crystallin subunit beta B1 [Bos taurus]; put. beta crystallin subunit beta B1; Beta-crystallin B1; Beta-B1 crystallin
Gene NamesCRYBB1
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
CAA25951 N/A N/A P07318 N/A N/A N/A bta:282205

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 253 aa

Average Mass: 28.143 kDa

Monoisotopic Mass: 28.126 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
--- cleavage 12 ---
--- cleavage 15 ---
DEC-1 protein, N-terminal region 1. 2771117.013.2
Beta/Gamma crystallin 1. 1051238.00.0
Peptidase inhibitor family I36 1. 1491777.00.1

3. Sequence Information

Fasta Sequence: SB0094.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

2 [sites] cleaved by Calpain 2

Source Reference: [PubMed ID: 9485487] Shih M, Lampi KJ, Shearer TR, David LL, Cleavage of beta crystallins during maturation of bovine lens. Mol Vis. 1998 Feb 27;4:4.

Cleavage sites (±10aa)


Ala12 Ala

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)


Asn15 Pro

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 6527379] Quax-Jeuken Y, Janssen C, Quax W, van den Heuvel R, Bloemendal H, Bovine beta-crystallin complementary DNA clones. Alternating proline/alanine sequence of beta B1 subunit originates from a repetitive DNA sequence. J Mol Biol. 1984 Dec 15;180(3):457-72.