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SB0095 : Crystallin, [beta]B3

[ CaMP Format ]

* Basic Information

OrganismRattus norvegicus (Norway rat)
Protein Namesbeta-crystallin B3 [Rattus norvegicus]; beta-crystallin B3; beta-B3 crystallin; Beta-crystallin B3; Beta-B3 crystallin; Beta-crystallin B3, N-terminally processed
Gene NamesCrybb3; crystallin, beta B3
Gene Locus12; chromosome 12
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_113878 NM_031690 64349 P02524 N/A N/A N/A rno:64349

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 211 aa

Average Mass: 24.276 kDa

Monoisotopic Mass: 24.261 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
--- cleavage 5 ---
--- cleavage 15 ---
--- cleavage 17 ---
Beta/Gamma crystallin 1. 251061.00.0
Phage Conserved Open Reading Frame 51 1. 14517624.00.2

3. Sequence Information

Fasta Sequence: SB0095.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

3 [sites] cleaved by Calpain 2

Source Reference: [PubMed ID: 8405363] David LL, Shearer TR, Beta-crystallins insolubilized by calpain II in vitro contain cleavage sites similar to beta-crystallins insolubilized during cataract. FEBS Lett. 1993 Jun 21;324(3):265-70.

Cleavage sites (±10aa)


His5 Gly

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)


Lys15 Ser

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)


His17 Gly

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 11773034] Lampi KJ, Shih M, Ueda Y, Shearer TR, David LL, Lens proteomics: analysis of rat crystallin sequences and two-dimensional electrophoresis map. Invest Ophthalmol Vis Sci. 2002 Jan;43(1):216-24.

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