logo CaMPDB: Calpain for Modulatory Proteolysis Database

SB0098 : Insulin-like growth factor binding protein 3

[ CaMP Format ]

* Basic Information

OrganismHomo sapiens (human)
Protein Namesinsulin-like growth factor-binding protein 3 isoform a precursor [Homo sapiens]; insulin-like growth factor-binding protein 3 isoform a precursor; IGF-binding protein 3; growth hormone-dependent binding protein; acid stable subunit of the 140 K IGF complex; binding protein 53; binding protein 29; IBP-3; IGFBP-3; Insulin-like growth factor-binding protein 3
Gene NamesIGFBP3; IBP3; insulin-like growth factor binding protein 3
Gene Locus7p12.3; chromosome 7
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_001013416 NM_001013398 3486 P17936 146732 HGNC:5472 00899 hsa:3486

* Information From OMIM

Description: The insulin-like growth factors (IGF), their receptors, and their binding proteins play key roles in regulating cell proliferation and apoptosis. Among the several roles of IGFBP3 are its function as the major carrying protein for IGF1 (OMIM:147440) and IGF2 (OMIM:147470) in the circulation, and its action as a modulator of IGF bioactivity and as a direct growth inhibitor in the extravascular tissue compartment, where it is expressed in a highly regulated manner (Ferry et al., 1999).

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* Structure Information

1. Primary Information

Length: 297 aa

Average Mass: 32.222 kDa

Monoisotopic Mass: 32.202 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Insulin-like growth factor binding protein 1. 40941.020.7
--- cleavage 175 ---
Insulin-like growth factor binding protein 2. 25427011.00.6

3. Sequence Information

Fasta Sequence: SB0098.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites] cleaved by Calpain 2

Source Reference: [PubMed ID: 17655506] Berg U, Bang P, Carlsson-Skwirut C, Calpain proteolysis of insulin-like growth factor binding protein (IGFBP) -2 and -3, but not of IGFBP-1. Biol Chem. 2007 Aug;388(8):859-63.

Cleavage sites (±10aa)


His175 Ser

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'

Sequence conservation (by blast)

* References

[PubMed ID: 24368776] Duron E, Vidal JS, Funalot B, Brunel N, Viollet C, Seux ML, Treluyer JM, Epelbaum J, Bouc YL, Hanon O, Insulin-like growth factor I, insulin-like growth factor binding protein 3, and atrial fibrillation in the elderly. J Gerontol A Biol Sci Med Sci. 2014 Aug;69(8):1025-32. doi:

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